INT203260

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.54
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 2 69.76 Quite High
cytokine 6 52.84 Quite High
metalloproteinase 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 219 99.84 Very High Very High Very High
Death 19 99.68 Very High Very High Very High
Cancer 322 98.74 Very High Very High Very High
Apoptosis 83 95.28 Very High Very High Very High
Stress 8 87.84 High High
Metastasis 109 82.80 Quite High
Disease 19 79.88 Quite High
Head & Neck Cancer 12 79.04 Quite High
Ovarian Cancer 30 77.04 Quite High
Nevus 66 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that in our Carboplatin resistant cells, caspase-3 (the main effector caspase) was not activated by Carboplatin alone, yet pre-treatment of YUMAC cells with Phenoxodiol for 2 or 4 hours resulted in decreased levels of XIAP, sensitization to Carboplatin, and remarkable activation of caspase-3.
Negative_regulation (decreased) of Gene_expression (levels) of XIAP
1) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.67 Pain Relevance 0
Phenoxodiol inhibition of XIAP expression in melanoma cells
Negative_regulation (inhibition) of Gene_expression (expression) of XIAP associated with melanoma
2) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.82 Pain Relevance 0
In addition to caspase inhibition, XIAP has a role in activation of the JNK pathway, with resultant MAP kinase pathway activation, leading to NF-?
Negative_regulation (inhibition) of Gene_expression (has) of XIAP
3) Confidence 0.39 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.67 Pain Relevance 0
TM treatment markedly downregulated XIAP protein expression in a time dependent manner (Fig. 6B).
Negative_regulation (downregulated) of Gene_expression (expression) of XIAP
4) Confidence 0.25 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.05 Pain Relevance 0.07
Furthermore, TM treatment significantly enhanced tumor cell anoikis by activating p38 MAPK cell death pathway and by downregulating XIAP survival protein expression.


Negative_regulation (downregulating) of Gene_expression (expression) of XIAP associated with cancer and death
5) Confidence 0.25 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.32 Pain Relevance 0.03

General Comments

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