INT203264

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
arm 1
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 57.68 Quite High
metalloproteinase 3 30.20 Quite Low
depression 5 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 226 100.00 Very High Very High Very High
Apoptosis 94 100.00 Very High Very High Very High
Stress 4 100.00 Very High Very High Very High
Melanoma 292 99.00 Very High Very High Very High
Disease 22 98.64 Very High Very High Very High
Malignant Neoplastic Disease 40 93.56 High High
Nevus 88 90.48 High High
Metastasis 62 76.48 Quite High
Death 17 74.32 Quite High
Severe Combined Immunodeficiency 11 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitization of melanoma cell lines to Carboplatin by Phenoxodiol and the association with XIAP levels
XIAP Binding (association) of associated with melanoma
1) Confidence 0.39 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.22 Pain Relevance 0
High XIAP was associated with advanced stage (metastatic) disease and thick lesions over 2 mm (p = 0.0003 and p = 0.0264, respectively).


XIAP Binding (associated) of associated with disease
2) Confidence 0.39 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.81 Pain Relevance 0
XIAP has been shown in other cancers to be associated with resistance to chemotherapy [17-19], as well as resistance to radiation therapy [20,21].
XIAP Binding (associated) of associated with cancer
3) Confidence 0.33 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.25 Pain Relevance 0
We are currently collecting specimens from a randomized clinical trial in which metastatic melanoma patients on the control arm are being treated with chemotherapy alone, and we will assess XIAP levels and the association with chemotherapy response.
XIAP Binding (association) of in arm associated with melanoma
4) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.09 Pain Relevance 0
SOD protects cells from oxidative stress by catalyzing the disproportionation of superoxide to hydrogen peroxide [47], whereas XIAP protein modulates oxidative stress by binding to apoptosis-inducing factor (AIF) [46].
XIAP Binding (binding) of associated with stress and apoptosis
5) Confidence 0.21 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.95 Pain Relevance 0.03

General Comments

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