INT203265

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 7.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
melanocytes 1
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 584 99.84 Very High Very High Very High
Cancer 208 99.28 Very High Very High Very High
Renal Cancer 8 98.36 Very High Very High Very High
Toxicity 24 98.18 Very High Very High Very High
Death 24 97.88 Very High Very High Very High
Lung Cancer 8 97.36 Very High Very High Very High
Apoptosis 168 97.24 Very High Very High Very High
Breast Cancer 8 96.84 Very High Very High Very High
Lymphatic System Cancer 8 96.24 Very High Very High Very High
Disease Progression 8 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although clinical toxicity data using the XIAP targeting drug AEG 35156 are pending, we believe that the approach of targeting XIAP in order to sensitize melanoma cells to chemotherapy is worthy of further investigation.
Regulation (targeting) of XIAP associated with toxicity and melanoma
1) Confidence 0.41 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.87 Pain Relevance 0
Targeting XIAP to sensitize cancer cells to chemotherapy is supported by a number of studies showing that over-expression of XIAP in cell lines confers chemotherapy resistance, and that down-regulation of XIAP results in activation of both the mitochondrial and death receptor pathways and sensitization to chemotherapy [17,19,57-59].
Regulation (regulation) of XIAP associated with cancer and death
2) Confidence 0.41 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.76 Pain Relevance 0
Down-regulation of XIAP in melanoma cells by siRNAs sensitizes these cells to TRAIL-induced apoptosis [24].
Regulation (regulation) of XIAP associated with melanoma and apoptosis
3) Confidence 0.41 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.31 Pain Relevance 0
XIAP mediates cell cycle arrest, via regulation of cyclins and cyclin-dependent kinase inhibitors (CDKIs), and is involved in receptor-mediated signaling [56].
Regulation (regulation) of XIAP
4) Confidence 0.36 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.68 Pain Relevance 0
Positive XIAP immunoreactivity was observed predominantly in the membranous/cytoplasmic compartment.
Regulation (immunoreactivity) of XIAP
5) Confidence 0.25 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.69 Pain Relevance 0
A number of drugs that directly target XIAP are in development, including antisense oligonucleotide molecules (AEG 35156, Aegra pharmaceuticals, Montreal, Canada) and small molecule inhibitors, as reviewed by Schimmer et al [15], and these inhibitors might enhance chemosensitivity in XIAP over-expressing tumors.
Regulation (target) of XIAP associated with cancer
6) Confidence 0.25 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.16 Pain Relevance 0
Zhang et al demonstrated up-regulation of XIAP in a limited number of melanoma cell lines [28], and Bowen et al demonstrated higher expression of XIAP in 4 melanoma cell lines than in normal melanocytes, and found an association between XIAP expression and resistance to chemotherapy and radiation therapy [29].
Regulation (regulation) of XIAP in melanocytes associated with melanoma
7) Confidence 0.25 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.34 Pain Relevance 0
Thus, targeting XIAP is likely to be a useful approach to overcoming resistance to chemotherapy.
Regulation (targeting) of XIAP
8) Confidence 0.25 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.13 Pain Relevance 0

General Comments

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