INT203271

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 11.28
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 3
fibroblasts 3
CHM (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 125 99.44 Very High Very High Very High
cva 14 91.92 High High
cytokine 66 5.00 Very Low Very Low Very Low
anesthesia 15 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
epidural 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 1826 100.00 Very High Very High Very High
Targeted Disruption 44 99.64 Very High Very High Very High
Injury 479 98.64 Very High Very High Very High
Intracranial Vasospasm 2 94.56 High High
Cv General 3 Under Development 14 91.92 High High
Stress 55 90.52 High High
Subcutaneous Emphysema 2 89.12 High High
Vascular System Injuries 30 84.52 Quite High
Disease 112 80.44 Quite High
Toxicity 33 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The altered cellular phenotype of fibroblasts and monocytes from CHM patients carrying knockouts and missense mutations of the CHM gene complement and expand the existing data resulting from knock down of the main transcript of the CHM gene in cultured human fetal RPE cells [47].
Transcription (transcript) of CHM gene in fibroblasts associated with targeted disruption and choroideremia
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 1.01 Pain Relevance 0
CHM subjects 1, 5, 7, 8, and 11 (CHM group 2) express CHM mRNA at levels similar to controls but the levels of CHM mRNA in CHM subjects 2, 4, 6 and 9 (CHM group 1) were 8–20 times lower (Fig. 3C).
Transcription (express) of CHM associated with choroideremia
2) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.87 Pain Relevance 0
Microarray and quantitative PCR analysis confirmed that fibroblasts and monocytes from CHM patients with different mutations express CHM mRNA at different levels.
Transcription (express) of CHM in monocytes associated with choroideremia
3) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.83 Pain Relevance 0
CHM subjects 1, 5, 7, 8, and 11 (CHM group 2) express CHM mRNA at levels similar to controls but the levels of CHM mRNA in CHM subjects 2, 4, 6 and 9 (CHM group 1) were 8–20 times lower (Fig. 3C).
Transcription (levels) of CHM associated with choroideremia
4) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.87 Pain Relevance 0
CHM subjects 1, 5, 7, 8, and 11 (CHM group 2) express CHM mRNA at levels similar to controls but the levels of CHM mRNA in CHM subjects 2, 4, 6 and 9 (CHM group 1) were 8–20 times lower (Fig. 3C).
Transcription (levels) of CHM associated with choroideremia
5) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0
Similar CHM mRNA levels were obtained for monocytes and fibroblasts derived from the same patient.
Transcription (levels) of CHM in fibroblasts associated with choroideremia
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.85 Pain Relevance 0
CHM subjects 1, 5, 7, 8, and 11 (CHM group 2) express CHM mRNA at levels similar to controls but the levels of CHM mRNA in CHM subjects 2, 4, 6 and 9 (CHM group 1) were 8–20 times lower (Fig. 3C).
Transcription (at) of CHM associated with choroideremia
7) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.87 Pain Relevance 0
Generally, low levels of CHM mRNA could be explained by nonsense-mediated decay of the transcript [31].
Transcription (levels) of CHM associated with choroideremia
8) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.93 Pain Relevance 0
Transcranial Doppler (TCD)
Transcription (Transcranial) of TCD
9) Confidence 0.35 Published 2007 Journal World J Emerg Surg Section Body Doc Link PMC1796545 Disease Relevance 0.45 Pain Relevance 0.08
Transcranial Doppler (TCD)
Transcription (Transcranial) of TCD
10) Confidence 0.35 Published 2007 Journal World J Emerg Surg Section Body Doc Link PMC1796545 Disease Relevance 1.01 Pain Relevance 0.09
The altered cellular phenotype of fibroblasts and monocytes from CHM patients carrying knockouts and missense mutations of the CHM gene complement and expand the existing data resulting from knock down of the main transcript of the CHM gene in cultured human fetal RPE cells [47].
Transcription (transcript) of CHM gene in monocytes associated with targeted disruption and choroideremia
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 1.01 Pain Relevance 0
Microarray and quantitative PCR analysis confirmed that fibroblasts and monocytes from CHM patients with different mutations express CHM mRNA at different levels.
Transcription (express) of CHM in fibroblasts associated with choroideremia
12) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.83 Pain Relevance 0
Similar CHM mRNA levels were obtained for monocytes and fibroblasts derived from the same patient.
Transcription (levels) of CHM in monocytes associated with choroideremia
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.85 Pain Relevance 0

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