INT203282

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
lymphocyte 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 98 88.64 High High
Central nervous system 14 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 99.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 140 91.44 High High
Pox Virus Infection 2 75.48 Quite High
Emergencies 12 50.00 Quite Low
Death 10 36.20 Quite Low
Viral Meningitis 14 5.00 Very Low Very Low Very Low
Dementia 12 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action of the small molecule BMS-378806 [77,78] remains controversial; it has been suggested that it suppresses infection by inhibition of CD4 binding [79,80] and/or affecting the CD4-induced conformational re-arrangement of gp120 and gp41 [81,82].
Negative_regulation (inhibition) of CD4 Binding (binding) of associated with infection
1) Confidence 0.30 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.19 Pain Relevance 0.11
g DNA of each CD4 and CCR5 expression vectors, or CD4 plus empty vector as negative control, and 3 ?
Negative_regulation (negative) of CD4 Neg (negative) Binding (control) of
2) Confidence 0.30 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.26 Pain Relevance 0
We also report receiver operating characteristic (ROC) curve area[5] for EQ-5D VAS as test measure and, as criterion measures, binary coded CD4+ lymphocyte count (<50, ?
Negative_regulation (coded) of CD4 Binding (count) of in lymphocyte
3) Confidence 0.28 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1796859 Disease Relevance 0.17 Pain Relevance 0

General Comments

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