INT203308

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.59
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
spinal cords 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 10 99.84 Very High Very High Very High
aspirin 15 98.00 Very High Very High Very High
Pain 48 97.12 Very High Very High Very High
Spinal cord 54 92.84 High High
Acute pain 4 85.24 High High
c fibre 12 84.76 Quite High
Dorsal horn 8 81.04 Quite High
Peripheral nervous system 12 72.56 Quite High
Central nervous system 18 72.08 Quite High
Neuropathic pain 16 69.20 Quite High
Disease Link Frequency Relevance Heat
Contusions 2 99.32 Very High Very High Very High
Toxicity 2 97.52 Very High Very High Very High
Injury 44 97.40 Very High Very High Very High
Pain 54 97.12 Very High Very High Very High
Spinal Cord Injury 2 92.84 High High
Apoptosis 10 89.80 High High
Targeted Disruption 20 89.32 High High
Motor Neuron Diseases 214 84.96 Quite High
Death 38 82.84 Quite High
Nociception 22 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of protein levels revealed an up-regulation for ANXA2 (18.56-fold) and AQP1 (4.94-fold), and a down-regulation of NRGN (0.38-fold) in diseased samples.
Regulation (regulation) of AQP1
1) Confidence 0.48 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0 Pain Relevance 0.03
Water and solute transport is represented by the up-regulation of AQP1 and SLC14A1.
Regulation (regulation) of AQP1
2) Confidence 0.48 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.91 Pain Relevance 0.06
AQP1 KO mice also have a significantly attenuated response to capsaicin, although not to the same degree as TRPV1 null mice where the response to capsaicin is completely lost.
Regulation (response) of AQP1 associated with qutenza
3) Confidence 0.42 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.57 Pain Relevance 0.92
Interestingly; AQP1 levels were not affected by long-lasting hypertonicity that significantly increased astrocytic AQP4, suggesting that the primary role of AQP1 is not regulating isotonicity in spinal cords.
Neg (not) Regulation (affected) of AQP1 in spinal cords
4) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.11 Pain Relevance 0.81
Results showed that aspirin treatment significantly decreases AQP6 mRNA expression (about 70%, Figure 3), while no significant changes were observed for AQP1, 2, 4 and 7 transcripts under this condition.
Neg (no) Regulation (changes) of AQP1 associated with aspirin
5) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.31

General Comments

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