INT203309

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.03 Pain Relevance 0.35

cytoskeletal protein binding (Anxa2) extracellular region (Anxa2) proteinaceous extracellular matrix (Anxa2) plasma membrane (Anxa2) protein complex (Anxa2) cytoplasm (Anxa2)

Anatomy Link Frequency hippocampus 1 Anxa2 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 18 100.00 Spinal cord 24 92.08 Inflammation 22 72.40 Peripheral nervous system 2 64.96 Central nervous system 6 54.88 Inflammatory response 16 5.00 gABA 6 5.00 antagonist 6 5.00 cytokine 4 5.00 Neurotransmitter 4 5.00

Disease Link Frequency Relevance Heat Disease 60 99.62 Motor Neuron Diseases 214 94.16 INFLAMMATION 40 72.40 Stress 44 69.20 Death 38 54.24 Neurodegenerative Disease 18 31.08 Parkinson's Disease 12 5.00 Hypoxia 12 5.00 Apoptosis 10 5.00 Targeted Disruption 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Quantification of protein levels revealed an up-regulation for ANXA2 (18.56-fold) and AQP1 (4.94-fold), and a down-regulation of NRGN (0.38-fold) in diseased samples.

Regulation (regulation) of ANXA2

1) Confidence 0.42 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0 Pain Relevance 0.03

In particular, ATP1A3, EGR1, and CHGB experience opposing deregulation in the SALS motor cortex compared to the AD hippocampus, with ANXA2, ATP6V1A, EIF4A2, NSF, and all the metallothioneins detected in the hippocampus (MT1E, MT1G, MT1X, MT2A) also showing markedly different regulation between both tissues.

Regulation (regulation) of ANXA2 in hippocampus associated with hippocampus and disease

2) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.03 Pain Relevance 0.32

General Comments

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