INT20331

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 31
Total Number 34
Disease Relevance 8.60
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1A2) oxidoreductase activity (CYP1A2) endoplasmic reticulum (CYP1A2)
enzyme binding (CYP1A2)
Anatomy Link Frequency
liver 3
plasma 2
1A2 2
skeletal muscle tissue 2
muscles 1
CYP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 84 100.00 Very High Very High Very High
Paracetamol 51 99.68 Very High Very High Very High
headache 28 97.48 Very High Very High Very High
carbamazepine 25 97.12 Very High Very High Very High
Leflunomide 1 96.40 Very High Very High Very High
antiepileptic Drug 25 95.24 Very High Very High Very High
lidocaine 2 94.80 High High
Endep 7 91.04 High High
Morphine 3 90.68 High High
Nortriptyline 1 90.44 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 112 99.84 Very High Very High Very High
Lung Cancer 16 99.76 Very High Very High Very High
Injury 6 98.00 Very High Very High Very High
Headache 28 97.48 Very High Very High Very High
Rhabdomyolysis 8 97.36 Very High Very High Very High
Hepatotoxicity 6 97.04 Very High Very High Very High
Congenital Anomalies 18 96.88 Very High Very High Very High
Toxicity 24 96.24 Very High Very High Very High
Chloracne 3 95.84 Very High Very High Very High
Sudden Death 1 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP1A2 is one of the major enzymes that bioactivate a number of procarcinogens and thus induction of CYP1A2 may increase the carcinogenicity of these compounds.
Positive_regulation (induction) of CYP1A2
1) Confidence 0.69 Published 2009 Journal Curr. Drug Metab. Section Abstract Doc Link 19702529 Disease Relevance 0 Pain Relevance 0.14
It is concluded that CYP1A2 induction seen in the Yucheng cohort is an excellent biomarker of exposure and human health effects in individual subjects and cohort.
Positive_regulation (induction) of CYP1A2
2) Confidence 0.69 Published 2006 Journal Environ. Sci. Technol. Section Abstract Doc Link 17051818 Disease Relevance 0.29 Pain Relevance 0.10
CYP1A2 activity was elevated in Yucheng subjects more than 2-fold and correlated with serum TEQ (R2= 0.62).
Positive_regulation (elevated) of CYP1A2
3) Confidence 0.69 Published 2006 Journal Environ. Sci. Technol. Section Abstract Doc Link 17051818 Disease Relevance 0.27 Pain Relevance 0.09
Induced CYP1A2 activity as a phenotypic biomarker in humans highly exposed to certain PCBs/PCDFs.
Positive_regulation (Induced) of CYP1A2
4) Confidence 0.69 Published 2006 Journal Environ. Sci. Technol. Section Title Doc Link 17051818 Disease Relevance 0 Pain Relevance 0
This suggests that induction of CYP1A2 activity by omeprazole is unlikely to increase the risk of acetaminophen hepatotoxicity.
Positive_regulation (induction) of CYP1A2 associated with paracetamol and hepatotoxicity
5) Confidence 0.69 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9246016 Disease Relevance 0.17 Pain Relevance 0.65
The results of this study show that, despite induction of CYP1A2 activity in slow metabolizers (a 75% increase in plasma clearance of caffeine), the formation of NAPQI from acetaminophen was not increased after 7 days of omeprazole administration (40 mg/day).
Positive_regulation (induction) of CYP1A2 in plasma associated with paracetamol
6) Confidence 0.69 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9246016 Disease Relevance 0.08 Pain Relevance 0.67
CYP1A2 activity, as determined by a caffeine metabolic ratio ((AFMU + 1X + 1U)/1, 7U), was multimodally distributed and was clearly increased in smokers.
Positive_regulation (distributed) of CYP1A2 associated with nicotine addiction
7) Confidence 0.67 Published 1994 Journal Pharmacogenetics Section Abstract Doc Link 7987405 Disease Relevance 0.61 Pain Relevance 0.43
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of CYP1A2 in placenta associated with nicotine addiction
8) Confidence 0.66 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Metabolized by several cytochrome P450 (CYP450) enzymes, modafinil is a mild inducer of CYP1A2, CYP2B6, CYP3A4, and is a mild inhibitor of CYP2C19 (Cephalon 2004).
Positive_regulation (inducer) of CYP1A2
9) Confidence 0.51 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654790 Disease Relevance 0.15 Pain Relevance 0.26
Smoking also dramatically increases activity of CYP1A2, another enzyme involved in erlotinib metabolism and this is hypothesized to be one reason for lack of efficacy of the drug in smokers, due to increased clearance (Li et al 2007).
Positive_regulation (increases) of CYP1A2 associated with nicotine addiction
10) Confidence 0.51 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.54 Pain Relevance 0
CYP1A2 was predominantly responsible for 3'-OH-genistein formation since its formation was inhibited (>50%, p < 0.05) by a monoclonal antibody specific for CYP1A2, was correlated with CYP1A2 activities of HLM, and was catalyzed by expressed CYP1A2.
Positive_regulation (activities) of CYP1A2
11) Confidence 0.50 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12814970 Disease Relevance 0 Pain Relevance 0
The discrepant observations in the literature regarding the clinical significance of the acetaminophen-warfarin interaction may be resolved if the hepatic enzyme activity of CYP1A2 and 3A4 is enhanced relative to CYP2E1 and the nonoxidative pathways of glucuronidation and sulfation responsible for acetaminophen metabolism.
Positive_regulation (enhanced) of CYP1A2 associated with paracetamol
12) Confidence 0.49 Published 2000 Journal Pharmacotherapy Section Abstract Doc Link 11130219 Disease Relevance 0.30 Pain Relevance 0.57
In examining the PIs affinity for CYP450 enzymes, lopinavir is a substrate of the enzyme CYP3A4, while ritonavir is a substrate of CYP1A2, 2B6, 2D6, and 3A4.
Positive_regulation (substrate) of CYP1A2
13) Confidence 0.49 Published 2010 Journal Int J Emerg Med Section Body Doc Link PMC2885261 Disease Relevance 0.29 Pain Relevance 0
A pharmacokinetic interaction between ciprofloxacin and the patient's comedication carbamazepine is unlikely to be the responsible mechanism, since fluoroquinolones inhibit cytochrome P450 isoenzyme CYP1A2 but not CYP3A4 which metabolizes carbamazepine.
Positive_regulation (cytochrome) of CYP1A2
14) Confidence 0.49 Published 2009 Journal Int J Clin Pharmacol Ther Section Body Doc Link 19281725 Disease Relevance 0 Pain Relevance 0
Although statistically significant increases in glucuronidation were observed for each reaction studied, the level of induction was less than that observed for CYP1A2 or CYP3A4 and exhibited a large interdonor variability.
Positive_regulation (increases) of CYP1A2
15) Confidence 0.48 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709631 Disease Relevance 0 Pain Relevance 0.27
Conversely, roflumilast does not induce CYP1A2, 2A6, 2C9, 2C19, and 3A4/5, and is only a weak inducer of CYP2B6.
Neg (not) Positive_regulation (induce) of CYP1A2
16) Confidence 0.47 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915539 Disease Relevance 0.24 Pain Relevance 0.04
In conclusion, the use of acetaminophen as prodrug and CYP1A2 as an activating enzyme is a promising combination for gene-directed enzyme prodrug therapy.
Positive_regulation (activating) of CYP1A2 associated with paracetamol
17) Confidence 0.47 Published 2000 Journal Cancer Gene Ther. Section Abstract Doc Link 10811468 Disease Relevance 0.27 Pain Relevance 0.44
CYP1A2 activity, as determined by a caffeine metabolic ratio ((AFMU + 1X + 1U)/1, 7U), was multimodally distributed and was clearly increased in smokers.
Positive_regulation (increased) of CYP1A2 associated with nicotine addiction
18) Confidence 0.45 Published 1994 Journal Pharmacogenetics Section Abstract Doc Link 7987405 Disease Relevance 0.61 Pain Relevance 0.43
CYP1A2 is expressed mainly in the liver and is induced by cigarette smoking [9].
Positive_regulation (induced) of CYP1A2 in liver associated with nicotine addiction
19) Confidence 0.38 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.44 Pain Relevance 0.10
Some drugs such as omeprazole may induce CYP1A2 activity [11].
Spec (may) Positive_regulation (induce) of CYP1A2
20) Confidence 0.38 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox