INT203311

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.87
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igfals) cell adhesion (Igfals) nucleus (Igfals)
Anatomy Link Frequency
astrocytes 2
upper 2
Igfals (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 47 99.16 Very High Very High Very High
Inflammatory mediators 20 97.20 Very High Very High Very High
Spinal cord 24 91.12 High High
Central nervous system 59 88.32 High High
Inflammation 67 87.12 High High
Inflammatory response 25 83.64 Quite High
medulla 7 67.28 Quite High
Glutamate receptor 6 66.44 Quite High
Neurotransmitter 10 65.64 Quite High
ischemia 6 54.64 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 171 100.00 Very High Very High Very High
Autoimmune Disease 16 100.00 Very High Very High Very High
Chronic Fatigue Syndrome 11 100.00 Very High Very High Very High
Dementia 10 100.00 Very High Very High Very High
Cognitive Disorder 9 100.00 Very High Very High Very High
Syndrome 2 100.00 Very High Very High Very High
Vascular Dementia 1 100.00 Very High Very High Very High
Neurodegenerative Disease 34 97.72 Very High Very High Very High
INFLAMMATION 122 96.80 Very High Very High Very High
Lifespan 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this way, we generated an ALS mouse model with attenuated VGLUT2-dependent glutamatergic signalling (46).
Positive_regulation (generated) of Gene_expression (generated) of ALS associated with motor neuron diseases
1) Confidence 0.16 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 1.08 Pain Relevance 0.21
may not be critical to ALS pathogenesis as genetic deletion of IL-1?
Neg (not) Positive_regulation (critical) of Gene_expression (pathogenesis) of ALS associated with motor neuron diseases
2) Confidence 0.07 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.21 Pain Relevance 0.21
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Positive_regulation (by) of Gene_expression (recognized) of ALS in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
3) Confidence 0.06 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.92 Pain Relevance 0.13
Furthermore, this deficiency is only observed in spinal motor neurons, whereas upper motor neurons, which also degenerate in ALS, showed unaltered editing levels of GluR-B.
Positive_regulation (degenerate) of Gene_expression (degenerate) of ALS in upper associated with motor neuron diseases
4) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.53 Pain Relevance 0.12
Perspectives for ALS therapy
Positive_regulation (Perspectives) of Gene_expression (therapy) of ALS associated with motor neuron diseases
5) Confidence 0.04 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.13 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox