INT203323

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 20
Disease Relevance 8.45
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Angptl4) extracellular space (Angptl4) extracellular region (Angptl4)
proteinaceous extracellular matrix (Angptl4)
Anatomy Link Frequency
F19 8
liver 2
gut 2
adipose tissue 1
cortex 1
Angptl4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 96.40 Very High Very High Very High
imagery 185 95.12 Very High Very High Very High
Inflammation 65 87.20 High High
Inflammatory response 9 82.12 Quite High
Pain 1 65.84 Quite High
cytokine 5 64.48 Quite High
Spinal cord 12 53.44 Quite High
chemokine 1 42.20 Quite Low
Inflammatory mediators 1 30.88 Quite Low
Inflammatory stimuli 1 14.20 Low Low
Disease Link Frequency Relevance Heat
Dyslipidemia /

Combined Dyslipidemia

18 99.56 Very High Very High Very High
Obesity 267 99.44 Very High Very High Very High
Hypoxia 6 99.16 Very High Very High Very High
Diabetes Mellitus 22 98.88 Very High Very High Very High
Colon Cancer 18 98.44 Very High Very High Very High
Sprains And Strains 54 98.36 Very High Very High Very High
Motor Neuron Diseases 107 95.96 Very High Very High Very High
Weight Gain 71 88.52 High High
INFLAMMATION 76 87.20 High High
Weight Loss 37 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, we still observed ANGPTL4 expression indicating that additional players are also regulating ANGPTL4 expression.
Gene_expression (expression) of ANGPTL4
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
We show that ANGPTL4 expression can be induced by an array of probiotic strains including F19.
Gene_expression (expression) of ANGPTL4 in F19 associated with sprains and strains
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.41 Pain Relevance 0
ANGPTL4 has been reported to be highly expressed in liver and adipose tissue [5], and plasma levels of the protein decrease on a chronic high-fat diet [4].
Gene_expression (expressed) of ANGPTL4 in liver associated with obesity
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.87 Pain Relevance 0.05
, we still observed ANGPTL4 expression indicating that additional players are also regulating ANGPTL4 expression.
Gene_expression (expression) of ANGPTL4
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
Conditioned media from F19 co-cultured with HCT116 cells was, on the contrary, sufficient, even when heat-inactivated, to increase ANGPTL4 expression.
Gene_expression (expression) of ANGPTL4 in F19
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.21 Pain Relevance 0
Combinatorial transfection of the different siRNAs did not result in cooperative effects on ANGPTL4 expression (data not shown).


Gene_expression (expression) of ANGPTL4
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
were downregulated by siRNA in HT29 cells induction of ANGPTL4 expression by F19 was markedly reduced (Figure 4B), revealing a partial nuclear receptor dependency for this gut microbiota mediated effect.
Gene_expression (expression) of ANGPTL4 in gut
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
In order to address the mechanism of action of F19, we monitored ANGPTL4 expression as a result of bacterial presence.
Gene_expression (expression) of ANGPTL4 in F19
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.36 Pain Relevance 0
The colon carcinoma cell line HCT116 was used to determine effects of selected gut microbiota on ANGPTL4 expression in colonocytes.
Gene_expression (expression) of ANGPTL4 in gut associated with colon cancer
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.23 Pain Relevance 0.09
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Gene_expression (expression) of ANGPTL4
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.40 Pain Relevance 0
Circulating ANGPTL4 levels were upregulated in the F19 supplemented group (Figure 1D).
Gene_expression (levels) of ANGPTL4 in F19
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.29 Pain Relevance 0.09
In contrast, the anaerobic commensal B. thetaiotaomicron, is unable to induce ANGPTL4 which is in line with the reported inability of whole flora to increase ANGPTL4 expression [6].
Gene_expression (expression) of ANGPTL4
12) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.41 Pain Relevance 0
One such factor is the Angiopoietin-like 4 protein (ANGPTL4, FIAF for fasting induced adipose factor, or PGAR for PPAR?
Gene_expression (for) of ANGPTL4
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.94 Pain Relevance 0.04
Serum levels of ANGPTL4 protein revealed an increasing trend within 2 weeks of colonization with F19 (Figure 5A).
Gene_expression (levels) of ANGPTL4 protein in F19
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.12 Pain Relevance 0
Co-culture experiments of colonic cell lines and F19 were set up in order to monitor any ensuing alterations in ANGPTL4 expression by qPCR.
Gene_expression (expression) of ANGPTL4 in F19
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.07 Pain Relevance 0.04
We observed that potentially secreted factors from F19 can induce ANGPTL4 gene expression, acting in part through the peroxisome proliferator activated receptors alpha and gamma.
Gene_expression (expression) of ANGPTL4 gene in F19
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.06 Pain Relevance 0.04
Further characterization of ANGPTL4 expression revealed that F19 upregulated ANGPTL4 mRNA in a dose and time dependent manner (Figure 2B–C).
Gene_expression (expression) of ANGPTL4 in F19
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.08 Pain Relevance 0.07
Therefore the differential expression of EGR1, ANGPTL4, and EDN1 indicates hypoxic conditions in the SALS motor cortex, tying in with a predisposition for ALS by mutation of angiogenin in man [106] and of vascular endothelial growth factor in mouse [107].
Gene_expression (expression) of ANGPTL4 in cortex associated with hypoxia and motor neuron diseases
18) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.51 Pain Relevance 0.24
ANGPTL4 has been reported to be highly expressed in liver and adipose tissue [5], and plasma levels of the protein decrease on a chronic high-fat diet [4].
Gene_expression (expressed) of ANGPTL4 in adipose tissue associated with obesity
19) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.87 Pain Relevance 0.05
Gut bacteria also suppress the expression and release of fasting induced adipose factor (Fiaf) from small intestine, resulting in increased activity of lipoprotein-lipase (LPL) in adipocytes and enhanced storage of liver-derived triglycerides [12], [13].
Gene_expression (expression) of adipose factor in liver associated with obesity
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.34 Pain Relevance 0.19

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