INT203328

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.56
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a5) plasma membrane (Slc12a5) intracellular (Slc12a5)
transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 2
Slc12a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 2 96.28 Very High Very High Very High
gABA 59 96.08 Very High Very High Very High
Neurotransmitter 20 94.92 High High
hyperexcitability 1 93.64 High High
potassium channel 1 92.44 High High
GABAergic 58 88.56 High High
medulla 4 68.36 Quite High
Action potential 10 64.28 Quite High
Glutamate receptor 13 45.60 Quite Low
nMDA receptor 8 31.32 Quite Low
Disease Link Frequency Relevance Heat
Stress 26 100.00 Very High Very High Very High
Targeted Disruption 18 98.32 Very High Very High Very High
Pain 3 96.28 Very High Very High Very High
Epilepsy 4 94.92 High High
Hypersensitivity 2 94.48 High High
Nervous System Injury 2 92.96 High High
Parkinson's Disease 6 69.68 Quite High
Dystonia 1 69.16 Quite High
Injury 1 66.56 Quite High
Death 19 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During early development, increased expression of SLC12A5 lowers the intraneuronal chloride concentration below its electrochemical equilibrium and allows GABA to act as an inhibitory neurotransmitter.
Positive_regulation (increased) of Gene_expression (expression) of SLC12A5 associated with neurotransmitter and gaba
1) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.51 Pain Relevance 0.23
Cortical neurons from KCC2 knock out mice exhibit an abnormal morphology of dendritic spines that can be rescued by overexpression of a transport inactive mutant of KCC2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of KCC2 in neurons associated with targeted disruption
2) Confidence 0.21 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.50 Pain Relevance 0.15
Surface expression and fast changes in the activity of KCC2 like during oxidative stress are mediated by regulating the phosphorylation state of KCC2 (Lee et al., 2007; Wake et al., 2007).
Positive_regulation (mediated) of Gene_expression (expression) of KCC2 associated with stress
3) Confidence 0.15 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.55 Pain Relevance 0.25

General Comments

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