INT203330

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
cortex 2
Sod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 75.68 Quite High
Inflammatory response 8 60.16 Quite High
Inflammation 11 58.88 Quite High
antagonist 3 31.04 Quite Low
gABA 3 15.20 Low Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 100.00 Very High Very High Very High
Motor Neuron Diseases 107 99.32 Very High Very High Very High
Disease Progression 2 64.24 Quite High
INFLAMMATION 20 59.76 Quite High
Disease 30 44.08 Quite Low
Neurodegenerative Disease 9 39.28 Quite Low
Diabetes Mellitus 2 28.80 Quite Low
Hypertension 1 27.76 Quite Low
Death 19 19.56 Low Low
Sleep Disorders 1 11.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, several candidate compounds for ALS therapy [123] address aspects of SOD1 mutants, such as oxidative stress, impaired metal binding, and defects in protein folding, that we have also identified as affected in the motor cortex of sporadic, non-SOD1-linked patients.
Negative_regulation (impaired) of SOD1 Binding (binding) of in cortex associated with stress and motor neuron diseases
1) Confidence 0.28 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.03 Pain Relevance 0.10

General Comments

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