INT20336

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 48
Total Number 52
Disease Relevance 19.26
Pain Relevance 15.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1) endoplasmic reticulum (CYP2E1)
enzyme binding (CYP2E1)
Anatomy Link Frequency
liver 6
lymphocytes 4
blood 1
hepatocytes 1
brain 1
CYP2E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1077 100.00 Very High Very High Very High
Nicotine 18 99.98 Very High Very High Very High
alcohol 377 99.92 Very High Very High Very High
tolerance 11 99.08 Very High Very High Very High
cytokine 68 97.28 Very High Very High Very High
isoflurane 9 92.92 High High
Inflammation 160 91.92 High High
opiate 4 87.60 High High
carbamazepine 6 87.56 High High
Central nervous system 10 85.72 High High
Disease Link Frequency Relevance Heat
Alcohol Addiction 42 99.98 Very High Very High Very High
Obesity 115 99.84 Very High Very High Very High
Nicotine Addiction 169 99.70 Very High Very High Very High
Alcoholic Liver Diseases 100 99.68 Very High Very High Very High
Diabetes Mellitus 23 99.62 Very High Very High Very High
Death 180 99.60 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 36 99.40 Very High Very High Very High
Nasopharynx Cancer 103 99.32 Very High Very High Very High
Injury 300 98.60 Very High Very High Very High
Necrosis 39 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol-inducible CYP2E1 is of interest because of its ability to metabolize and activate many toxicologically important substrates including ethanol, CCl(4), acetaminophen, and N-nitrosodimethylamine, to more toxic products.
Positive_regulation (inducible) of CYP2E1 associated with paracetamol
1) Confidence 0.70 Published 2007 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 17567472 Disease Relevance 0.13 Pain Relevance 0.16
We present a model based on experimental studies of chemical induction of CYP2E1 by ligand stabilization through which this mechanism of induction can be translated into its pharmacokinetic consequence with regard to clearance of substrate.
Positive_regulation (induction) of CYP2E1
2) Confidence 0.70 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321520 Disease Relevance 0 Pain Relevance 0
Ligand stabilization therefore results in induction of CYP2E1 as enzyme accumulates as a consequence of unchanged synthesis.
Positive_regulation (induction) of CYP2E1
3) Confidence 0.70 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321520 Disease Relevance 0 Pain Relevance 0
Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization.
Positive_regulation (induction) of CYP2E1
4) Confidence 0.70 Published 1997 Journal Drug Metab. Dispos. Section Title Doc Link 9321520 Disease Relevance 0 Pain Relevance 0
Induction of CYP2E1 does not always conform to this model, in that many chemicals induce the enzyme through stabilization of the protein apparently by binding to the active site.
Positive_regulation (Induction) of CYP2E1
5) Confidence 0.70 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321520 Disease Relevance 0 Pain Relevance 0
CYP2E1 induction is relevant because this enzyme activates many xenobiotics to become ultimate toxicants (Guengerich and Shimada 1991).
Positive_regulation (induction) of CYP2E1
6) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.24 Pain Relevance 0.04
We investigated the effects of toluene exposure on expression of the CYP2E1 phenotype by measuring CYP2E1 mRNA induction in peripheral lymphocytes and CHZ metabolism in workers exposed to organic solvents and then determining whether these mRNA content and CHZ metabolic data were associated with genotype.
Positive_regulation (induction) of CYP2E1 mRNA in lymphocytes
7) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.11 Pain Relevance 0.03
Such inter-individual differences are likely to result from several factors: a) differing toluene exposures that lead to different hippuric acid production; b) a competitive inhibition of toluene metabolism by other VOCs, which was greater in workers exposed to high toluene concentrations; c) differing metabolic statuses, depending upon individual genetic characteristics and the extent of CYP2E1 induction; and d) possible development of a tolerance to toluene, as has been described for other CYP2E1 substrates (Shayiq et al. 1999).
Positive_regulation (induction) of CYP2E1 associated with tolerance
8) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0.05
In fact, CYP2E1 induction is the first step leading to the development of certain chemically mediated cancers (Lieber 1997).
Positive_regulation (induction) of CYP2E1 associated with cancer
9) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.26 Pain Relevance 0.04
CHZ biotransformation is related to CYP2E1 activity (Lucas et al. 1999), which is induced by toluene (Uaki et al. 1995).
Positive_regulation (induced) of CYP2E1
10) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0.04
Lymphocytes were also able to biotransform acetaminophen through the formation of the main metabolite paracetamidofenil-beta-glucuronide, which is the product of glucuronidation reaction, as a result of the Hypericum perforatum administration that induced the catalytic activity of the CYP2E1.
Positive_regulation (induced) of CYP2E1 in Lymphocytes associated with paracetamol
11) Confidence 0.69 Published 2007 Journal J. Biotechnol. Section Abstract Doc Link 17905461 Disease Relevance 0.06 Pain Relevance 0.17
John's wort) in order to induce cytochrome P450s enzymes, CYP2E, involved in the biotransformation of endogenous molecules and exogenous compounds.
Positive_regulation (induce) of CYP2E
12) Confidence 0.69 Published 2007 Journal J. Biotechnol. Section Abstract Doc Link 17905461 Disease Relevance 0.08 Pain Relevance 0.15
It seems to increase blood flow and the elimination of sevoflurane due to the induction of CYP2E1.
Positive_regulation (induction) of CYP2E1 in blood
13) Confidence 0.68 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2905413 Disease Relevance 1.07 Pain Relevance 0.04
Our laboratory has found in an intraindividual study that cigarette smoking significantly enhances CYP2E1 activity as measured by the clearance of chlorzoxazone.
Positive_regulation (enhances) of CYP2E1 associated with nicotine addiction
14) Confidence 0.68 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.66 Pain Relevance 0.05
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of CYP2E1 in placenta associated with nicotine addiction
15) Confidence 0.68 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Alcohol can affect the pharmacokinetics of drugs by altering gastric emptying or liver metabolism (by inducing cytochrome P450 2E1).
Positive_regulation (inducing) of cytochrome P450 2E1 in liver associated with alcohol
16) Confidence 0.67 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9260032 Disease Relevance 0 Pain Relevance 0.67
Obesity, untreated diabetes mellitus and alcohol abuse increase the hepatic content and activity of cytochrome P450 2E1 and therefore enhanced anaesthetic defluorination is to be suspected.
Positive_regulation (increase) of cytochrome P450 2E1 associated with diabetes mellitus, obesity and alcohol
17) Confidence 0.67 Published 1998 Journal Anaesthesist Section Abstract Doc Link 9893876 Disease Relevance 0.43 Pain Relevance 0.39
However, barbiturates as well as phenytoin do not influence the metabolism of sevoflurane because these agents do not induce the major hepatic defluorinating enzyme cytochrome P450 2E1.
Neg (not) Positive_regulation (induce) of cytochrome P450 2E1
18) Confidence 0.67 Published 1998 Journal Anaesthesist Section Abstract Doc Link 9893876 Disease Relevance 0.48 Pain Relevance 0.41
These results indicate that humans are not uniform in their capacity for CYP-dependent metabolism of TRI and increased CYP2E1 activity may increase susceptibility to TRI-induced toxicity in the human.
Positive_regulation (increased) of CYP2E1 associated with toxicity
19) Confidence 0.66 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9070354 Disease Relevance 0.30 Pain Relevance 0.09
The alcohol-induced induction of CYP2E1 wanes following alcohol abstinence with a half-life of approximately 2.5 days and CYP2E1 activity reaching normal in 3 to 8 days [12,25,28].
Positive_regulation (induction) of CYP2E1 associated with alcohol
20) Confidence 0.62 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.41 Pain Relevance 0.66

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