INT203362

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Angptl4) extracellular space (Angptl4) extracellular region (Angptl4)
proteinaceous extracellular matrix (Angptl4)
Anatomy Link Frequency
adipocytes 1
Angptl4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 84.96 Quite High
Spinal cord 12 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 12 97.32 Very High Very High Very High
Weight Gain 3 84.88 Quite High
Weight Loss 2 82.08 Quite High
Disease 31 81.44 Quite High
Diabetes Mellitus 3 80.56 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 78.96 Quite High
Stress 22 78.48 Quite High
Motor Neuron Diseases 107 70.08 Quite High
Parkinson's Disease 6 68.80 Quite High
Chronic Disease 1 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANGPTL4 is a circulating lipoprotein lipase (LPL) inhibitor and plays a key role in regulating deposition of triglycerides in adipocytes [2], [3].
Negative_regulation (inhibitor) of ANGPTL4 in adipocytes associated with obesity
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.94 Pain Relevance 0.04
At the level of individual genes, significant changes in gene expression similarly indicate a reduction of glycolysis (ANGPTL4) and glucose availability (CHGB, SCG5, PCSK1).
Negative_regulation (reduction) of ANGPTL4
2) Confidence 0.29 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.61 Pain Relevance 0

General Comments

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