INT20343

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Context Info
Confidence 0.63
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 5.01
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
brain 4
NAcb 4
pituitary 4
plasma 2
Leydig cells 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 36 99.98 Very High Very High Very High
Nucleus accumbens 40 99.68 Very High Very High Very High
Central grey 4 99.68 Very High Very High Very High
Calcium channel 5 99.08 Very High Very High Very High
Morphine 2 98.88 Very High Very High Very High
spinal dorsal horn 3 97.76 Very High Very High Very High
cytokine 10 97.24 Very High Very High Very High
sodium channel 7 97.12 Very High Very High Very High
antagonist 8 97.08 Very High Very High Very High
Dorsal horn 1 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 11 99.84 Very High Very High Very High
Nociception 6 99.74 Very High Very High Very High
Urological Neuroanatomy 21 99.68 Very High Very High Very High
Anxiety Disorder 5 99.32 Very High Very High Very High
Stress 14 97.04 Very High Very High Very High
INFLAMMATION 32 96.84 Very High Very High Very High
Body Weight 6 93.48 High High
Hyperalgesia 4 84.40 Quite High
Adhesions 1 83.36 Quite High
Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that AA could obviously stimulate the release of beta-EP from pituitary cells at a concentration of 2 x 10(-5) mol/L, while cortisol at 10(-6)mol/L and DEX at 10(-7)mol/L inhibited this release.
Positive_regulation (stimulate) of Localization (release) of beta-EP in pituitary associated with dexamethasone
1) Confidence 0.63 Published 1994 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 7954966 Disease Relevance 0 Pain Relevance 0.14
Constant exposure to ethanol at doses of 6-50 mM produced a dose-dependent increase in basal secretion of beta-EP from these cultured cells.
Positive_regulation (increase) of Localization (secretion) of beta-EP
2) Confidence 0.61 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.05
The depolarization-induced IR-beta EP release was dependent upon calcium, since a calcium channel blocker, verapamil (0.1 microM), prevented the release; also a calcium ionophore, A23187 (1 microM), stimulated IR-beta EP release in the cultures.
Positive_regulation (stimulated) of Localization (release) of EP associated with calcium channel
3) Confidence 0.45 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.21
When incubated with pituitary cells, lanthanum chloride induced a dose- and time-dependent release of beta-EP.
Positive_regulation (induced) of Localization (release) of beta-EP in pituitary
4) Confidence 0.42 Published 1994 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 7954966 Disease Relevance 0 Pain Relevance 0.19
Namely, beta-EP release continuously increased for a period under the action of La3+ of different doses (10(-5)mol/L and 10(-7)mol/L). beta-EP content in cells showed similar changes.
Positive_regulation (increased) of Localization (release) of beta-EP
5) Confidence 0.37 Published 1994 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 7954966 Disease Relevance 0 Pain Relevance 0.19
Ethanol-stimulated beta-EP secretion required extracellular calcium and was blocked by a calcium channel blocker; a sodium channel blocker did not affect ethanol-stimulated secretion.
Positive_regulation (stimulated) of Localization (secretion) of beta-EP associated with calcium channel and sodium channel
6) Confidence 0.36 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.17
The stimulated secretion of beta-EP following constant ethanol exposure is short-lasting.
Positive_regulation (stimulated) of Localization (secretion) of beta-EP
7) Confidence 0.36 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.07
Previous studies demonstrated that both the spontaneous and ethanol-stimulated release of beta-endorphin (beta-EP) like-peptides (beta-EPLPs) by the hypothalami of the ethanol-preferring C57BL/6 mice is more pronounced than by the hypothalami of the ethanol-avoiding DBA/2 mice.
Positive_regulation (ethanol-stimulated) of Localization (release) of beta-EP
8) Confidence 0.35 Published 1994 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 7695046 Disease Relevance 0 Pain Relevance 0.19
Both tail-pinch and fox odour significantly increased beta-EP release from the ArcN (P<0.05), whilst only tail-pinch enhanced beta-EP release from the NAcb (P<0.01).
Positive_regulation (increased) of Localization (release) of beta-EP in NAcb associated with nucleus accumbens
9) Confidence 0.32 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.23 Pain Relevance 0.36
In conclusion, the fact that physical and fear-inducing psychological stressors stimulate beta-EP release in the ArcN and only physical stressors stimulate beta-EP release in the NAcb, indicates that stressors with different properties are processed differently in the brain.
Positive_regulation (stimulate) of Localization (release) of beta-EP in brain associated with nucleus accumbens and anxiety disorder
10) Confidence 0.32 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.24 Pain Relevance 0.45
In conclusion, the fact that physical and fear-inducing psychological stressors stimulate beta-EP release in the ArcN and only physical stressors stimulate beta-EP release in the NAcb, indicates that stressors with different properties are processed differently in the brain.
Positive_regulation (stimulate) of Localization (release) of beta-EP in brain associated with nucleus accumbens and anxiety disorder
11) Confidence 0.32 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.25 Pain Relevance 0.44
The depolarization-induced IR-beta EP release was dependent upon calcium, since a calcium channel blocker, verapamil (0.1 microM), prevented the release; also a calcium ionophore, A23187 (1 microM), stimulated IR-beta EP release in the cultures.
Positive_regulation (dependent) of Localization (release) of EP associated with calcium channel
12) Confidence 0.30 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.20
Both tail-pinch and fox odour significantly increased beta-EP release from the ArcN (P<0.05), whilst only tail-pinch enhanced beta-EP release from the NAcb (P<0.01).
Positive_regulation (enhanced) of Localization (release) of beta-EP in NAcb associated with nucleus accumbens
13) Confidence 0.28 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.23 Pain Relevance 0.39
On the other hand, alcohol stimulated beta-EP release in the NAcb as compared with saline-treated controls (P<0.01), but not in the ArcN.
Positive_regulation (stimulated) of Localization (release) of beta-EP in ArcN associated with nucleus accumbens and alcohol
14) Confidence 0.28 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.23 Pain Relevance 0.42
CONCLUSION: Both low-frequency and high-frequency EA of "Zusanli (ST 36)" can effectively relieve gastric distension-induced gastralgia in the rat, and the effect of high-frequency EA is better, which may be closely related to its actions in promoting the release and synthesis of hypothalamic beta-EP and SP.


Positive_regulation (promoting) of Localization (release) of beta-EP
15) Confidence 0.27 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19916289 Disease Relevance 0 Pain Relevance 0
Beta-EP completely blocked ovulatory LH release induced by the electrochemical stimulation of the medial amygdaloid nucleus and medial septum-diagonal band of Broca, but failed to block ovulation due to the stimulation of the medial preoptic area (MPO) or median eminence, though serum LH levels after the MPO stimulation were inhibited by beta-EP.
Positive_regulation (induced) of Localization (release) of Beta-EP in MPO associated with urological neuroanatomy
16) Confidence 0.19 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6319110 Disease Relevance 0.28 Pain Relevance 0.07
These results demonstrate that beta EP is released from fetal Leydig cells in culture and that acute stimulation of Leydig cells by hCG can enhance beta EP secretion.
Positive_regulation (enhance) of Localization (secretion) of EP in Leydig cells
17) Confidence 0.18 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.20
It is thus suggested that nociceptive stimulation induce the release of beta-EP in the PAG, which, in turn, modulate SP release in the spinal dorsal horn.
Positive_regulation (induce) of Localization (release) of beta-EP in dorsal horn associated with nociception, spinal dorsal horn and central grey
18) Confidence 0.17 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7526471 Disease Relevance 0.53 Pain Relevance 0.63
These results suggest that 5-HT is a potent stimulator of both beta-EP and ACTH release and the increase in plasma concentrations of ACTH and beta-EP induced by stress are probably mediated, at least in part, by central serotonergic mechanisms.
Positive_regulation (stimulator) of Localization (release) of beta-EP in plasma associated with stress
19) Confidence 0.14 Published 1982 Journal Life Sci. Section Abstract Doc Link 6283286 Disease Relevance 0.27 Pain Relevance 0.40
The secretion of beta-EP and PRL was stimulated by both morphine and U-50,488H, and the influence of U-50,488H upon the release of beta-EP (from the adenohypophysis) was enhanced in arthritic rats.
Positive_regulation (enhanced) of Localization (release) of beta-EP in adenohypophysis associated with arthritis and morphine
20) Confidence 0.11 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3027278 Disease Relevance 1.31 Pain Relevance 1.16

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