INT203436

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.88
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
anterior 2
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 348 100.00 Very High Very High Very High
Neurotransmitter 11 96.92 Very High Very High Very High
Nerve growth factor 2 85.52 High High
nociceptor 64 70.76 Quite High
gABA 6 39.80 Quite Low
5HT 3 38.92 Quite Low
Somatostatin 15 38.08 Quite Low
calcitonin gene related peptide 22 32.56 Quite Low
Neuropeptide 14 17.36 Low Low
GABA receptor 3 16.28 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 380 100.00 Very High Very High Very High
Targeted Disruption 140 100.00 Very High Very High Very High
Death 4 99.92 Very High Very High Very High
Neurodegenerative Disease 24 94.72 High High
Repression 26 50.80 Quite High
Adhesions 3 32.00 Quite Low
Nociception 9 23.64 Low Low
Pain 9 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Brn3a expression resulted in increased expression of essentially all of the anterior HoxA, HoxB and HoxC genes, and the changes reached statistical significance (p < 0.005 or p > 0.995, Materials and Methods) for seven genes in this group (Figure 5).
Negative_regulation (Loss) of Gene_expression (expression) of Brn3a in anterior
1) Confidence 0.57 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.22 Pain Relevance 0
The loss of Brn3a expression in the developing DRG leads to marked changes in the expression of specific neurotransmitters, receptors, developmental regulators, mediators of signal transduction, and transcription factors.
Negative_regulation (loss) of Gene_expression (expression) of Brn3a associated with neurotransmitter
2) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.79 Pain Relevance 0.26
The abnormally persistent co-expression of TrkB and TrkC in the Brn3a-/- TG, and the subsequent loss of TrkC expression, are all consistent with effects mediated by Runx3.
Negative_regulation (loss) of Gene_expression (expression) of Brn3a associated with trigeminal ganglion
3) Confidence 0.42 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.73 Pain Relevance 0.48
One approach to understanding the cell-specific effects of the loss of Brn3a expression is suggested by recent work in which we have demonstrated a correlation between Brn3a binding to its target sites in vivo and H3-acetylation in the vicinity of the potential binding sites [[27] in press].
Negative_regulation (loss) of Gene_expression (expression) of Brn3a
4) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.42 Pain Relevance 0.18
Cell death is limited in the Brn3a knockout
Negative_regulation (limited) of Gene_expression (knockout) of Brn3a associated with targeted disruption and death
5) Confidence 0.36 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.72 Pain Relevance 0.22

General Comments

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