INT20344

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Context Info
Confidence 0.49
First Reported 1987
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 1.97
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
hypothalamus 2
ArcN 2
lymphocytes 2
brain 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 11 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Nucleus accumbens 8 98.60 Very High Very High Very High
alcohol 17 97.84 Very High Very High Very High
Morphine 6 97.08 Very High Very High Very High
agonist 15 96.68 Very High Very High Very High
opioid receptor 2 95.08 Very High Very High Very High
Analgesic 4 93.64 High High
pressure hyperalgesia 1 89.00 High High
Inflammation 9 86.32 High High
Disease Link Frequency Relevance Heat
Nociception 4 99.70 Very High Very High Very High
Influenza Virus Infection 92 92.80 High High
Arthritis 13 91.72 High High
Hyperalgesia 4 89.00 High High
INFLAMMATION 11 86.32 High High
Pressure Volume 2 Under Development 1 76.68 Quite High
Stress 3 75.00 Quite High
Pain 3 75.00 Quite High
Hypoalagesia 2 71.00 Quite High
Body Weight 3 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of the present studies was to investigate the effects of various concentrations of ethanol on the in vitro release of beta-EP peptides by the hypothalami of the ethanol-preferring Alko-Alcohol (AA) and ethanol-avoiding Alko Non-Alcohol (ANA) lines of rats.
Spec (investigate) Regulation (effects) of Localization (release) of beta-EP associated with alcohol
1) Confidence 0.49 Published 1994 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 7695046 Disease Relevance 0 Pain Relevance 0.33
In conclusion, the RAT method favorably modulates the secretion of beta-EP during labor and at delivery.
Regulation (modulates) of Localization (secretion) of beta-EP
2) Confidence 0.30 Published 1994 Journal J Psychosom Obstet Gynaecol Section Abstract Doc Link 7881506 Disease Relevance 0.07 Pain Relevance 0.07
The aim of the present study was to determine the effects of distinct categories of stressors on beta-endorphin (beta-EP) release in the arcuate nucleus (ArcN) and nucleus accumbens (NAcb) using in vivo microdialysis.
Spec (determine) Regulation (effects) of in arcuate nucleus Localization (release) of beta-EP in ArcN associated with nucleus accumbens
3) Confidence 0.29 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.13 Pain Relevance 0.22
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Regulation (role) of Localization (release) of Ep
4) Confidence 0.26 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
To evaluate the influence of membrane depolarization on IR-beta EP release, the cells were challenged with 56 mM potassium.
Regulation (influence) of Localization (release) of EP
5) Confidence 0.18 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.17
We have now examined the effects of the opioid antagonist naltrexone on beta-EP processing in the hypothalamus and on the release of 2 POMC-derived peptides, beta-EP and gamma 3-MSH, from the perifused hypothalamus in vitro.
Spec (examined) Regulation (effects) of Localization (release) of beta-EP in hypothalamus associated with antagonist and opioid
6) Confidence 0.16 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922523 Disease Relevance 0 Pain Relevance 0.38
BACKGROUND: We have previously shown that alcohol suppresses the natural killer (NK) cell activity of splenic lymphocytes partly by reducing the secretion of opioid peptide beta-endorphin (beta-EP) and its positive influence on NK-cell cytolytic activity in rats.
Regulation (influence) of Localization (secretion) of beta-EP in lymphocytes associated with opioid and alcohol
7) Confidence 0.14 Published 2002 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 12436062 Disease Relevance 0 Pain Relevance 0.15
These effects were specific to nociception in that their influence upon endocrine secretion (PRL and beta-EP) was otherwise changed.
Regulation (influence) of Localization (secretion) of beta-EP associated with nociception
8) Confidence 0.11 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3027278 Disease Relevance 1.34 Pain Relevance 1.18
The results suggested that scopolamine might modulate hypothalamus-pituitary system to affect the release or synthesis of beta-EP and OT in the brain.
Regulation (affect) of Localization (release) of beta-EP in brain
9) Confidence 0.10 Published 1995 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 7600326 Disease Relevance 0 Pain Relevance 0.31
To study the effects of naltrexone on beta-EP and gamma 3-MSH release, hypothalami were perifused in vitro with 10(-6) M naltrexone.
Regulation (effects) of Localization (release) of beta-EP
10) Confidence 0.10 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922523 Disease Relevance 0 Pain Relevance 0.39
Vaccinees given CpG ODN plus either a full or a reduced (0.1) dose of Fluarix had similar hemagglutinin inhibition and anti-HA antibody titres, but antigen-specific IFN-?
Regulation (Vaccinees) of Localization (given) of ODN
11) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.35 Pain Relevance 0.03

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