INT203441

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.35
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 4
ganglia 2
neurites 2
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 110 99.98 Very High Very High Very High
trigeminal ganglion 368 99.96 Very High Very High Very High
nociceptor 130 97.88 Very High Very High Very High
Acute pain 4 91.84 High High
Serotonin 9 81.00 Quite High
Central nervous system 17 80.56 Quite High
Spinal cord 31 72.40 Quite High
Peripheral nervous system 4 60.24 Quite High
cerebral cortex 1 53.92 Quite High
Somatostatin 15 39.84 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 224 100.00 Very High Very High Very High
Ganglion Cysts 526 99.98 Very High Very High Very High
Pain 13 91.84 High High
Nociception 37 90.84 High High
Neurodegenerative Disease 26 86.84 High High
Repression 38 75.32 Quite High
Apoptosis 4 70.12 Quite High
Cancer 6 64.52 Quite High
Death 12 57.88 Quite High
Bone Cancer 2 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Positive_regulation (initiation) of Gene_expression (expression) of Runx3
1) Confidence 0.66 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.78 Pain Relevance 0.62
Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].
Neg (not) Positive_regulation (extended) of Gene_expression (explants) of Runx3-knockout in neurites associated with targeted disruption and dorsal root ganglion
2) Confidence 0.49 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.93 Pain Relevance 0.34
Subsequently, the generation of specific antibodies against Runx1 and Runx3 and the utilization of Runx1?
Positive_regulation (generation) of Gene_expression (antibodies) of Runx3
3) Confidence 0.49 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.73 Pain Relevance 0.30
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Positive_regulation (populations) of Gene_expression (expressing) of Runx3 in ganglia
4) Confidence 0.48 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors.
Positive_regulation (initiated) of Gene_expression (expression) of Runx3 in neurons associated with nociceptor
5) Confidence 0.48 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.36
In control TG, Runx3 expression follows TrkC by one developmental day.
Positive_regulation (follows) of Gene_expression (expression) of Runx3 associated with trigeminal ganglion
6) Confidence 0.48 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.63 Pain Relevance 0.48
In contrast, expression of Runx3, an earlier and more general marker of proprioceptive neurons [13,14], was noted in both the DRG and TG at E13.5 (Figure 2c, d).
Positive_regulation (noted) of Gene_expression (expression) of Runx3 in neurons associated with trigeminal ganglion
7) Confidence 0.38 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.49 Pain Relevance 0.27

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