INT203443

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 11.12
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Isl1) intracellular (Isl1) DNA binding (Isl1)
Anatomy Link Frequency
telencephalon 2
TEK 2
macrophages 1
sensory neurons 1
telencephalic 1
Isl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 346 100.00 Very High Very High Very High
cytokine 240 100.00 Very High Very High Very High
gABA 206 100.00 Very High Very High Very High
chemokine 42 99.52 Very High Very High Very High
amygdala 384 98.38 Very High Very High Very High
agonist 49 98.08 Very High Very High Very High
trigeminal ganglion 141 95.36 Very High Very High Very High
substance P 33 86.96 High High
Nucleus accumbens 6 85.92 High High
Nerve growth factor 1 85.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 346 100.00 Very High Very High Very High
Apoptosis 111 99.76 Very High Very High Very High
Death 158 99.66 Very High Very High Very High
Myocardial Infarction 92 98.36 Very High Very High Very High
Targeted Disruption 94 98.24 Very High Very High Very High
Diabetes Mellitus 902 97.76 Very High Very High Very High
Ganglion Cysts 155 97.54 Very High Very High Very High
Stress 63 96.92 Very High Very High Very High
Neurodegenerative Disease 9 93.68 High High
Obesity 16 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Foxd3 and Isl1 are normally expressed in postmitotic populations that do not express Lbx1.
Gene_expression (expressed) of Isl1
1) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
In the case of P. waltl, an amygdaloid area called “amygdala pars lateralis” (Northcutt and Kicliter, 1980) was defined and now we know that expresses GABA and Isl1, possesses Nkx2.1 scattered cells, and receives a vomeronasal/olfactory projection that could be processed and relayed to the ventral hypothalamus.
Gene_expression (expresses) of Isl1 in ventral associated with gaba and amygdala
2) Confidence 0.54 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.31
Regional markers: telencephalic expression of NOS, Isl1, GABA, and Nkx2.1
Gene_expression (expression) of Isl1 in telencephalic associated with gaba
3) Confidence 0.54 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.20
In particular, Isl1 expression in the telencephalon is restricted to the LGE during development (Stenman et al., 2003) and it was associated with the cholinergic phenotype in several neural systems (Ericson et al., 1992; Galli-Resta et al., 1997, Moreno and González, 2006; Wang and Liu, 2001), and also with the control of the axon guidance in the telencephalon (López-Bendito et al., 2006).
Gene_expression (expression) of Isl1 in neural
4) Confidence 0.54 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.06
We found that Nkx2.1, Isl1, GABA, and NOS are expressed in unique and conserved patterns that mark specific regions of the telencephalon.
Gene_expression (expressed) of Isl1 in telencephalon associated with gaba
5) Confidence 0.54 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.12
We found that Nkx2.1, Isl1, GABA, and NOS are expressed in unique and conserved patterns that mark specific regions of the telencephalon.
Gene_expression (expressed) of Isl1 in telencephalon associated with gaba
6) Confidence 0.47 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.12
The anti-Isl1 antibody was generated in mouse against a 25?
Gene_expression (antibody) of Isl1
7) Confidence 0.47 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0
In addition, the expression of the territorial transcription factors ISL1 and NKX2.1 showed that this area is rich in cells that expressed ISL1 and almost totally lacks cells labeled for NKX2.1 (Figures 6C,D).
Gene_expression (expressed) of ISL1
8) Confidence 0.32 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0.45
To study the co-localization or co-distribution of two proteins in the same sections, different two-step protocols for immunohistofluorecence were used with antibody cocktails as follows: pairs of primary antibodies developed one in rabbit and one in mouse were used in a cocktail, with the same dilution and characteristics as described above for the single labeling (combinations: CB/TH, OTP/ISL1, CB/Go?
Gene_expression (/) of ISL1
9) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0
To study the co-localization or co-distribution of two proteins in the same sections, different two-step protocols for immunohistofluorecence were used with antibody cocktails as follows: pairs of primary antibodies developed one in rabbit and one in mouse were used in a cocktail, with the same dilution and characteristics as described above for the single labeling (combinations: CB/TH, OTP/ISL1, CB/Go?
Gene_expression (/) of ISL1
10) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0
To study the co-localization or co-distribution of two proteins in the same sections, different two-step protocols for immunohistofluorecence were used with antibody cocktails as follows: pairs of primary antibodies developed one in rabbit and one in mouse were used in a cocktail, with the same dilution and characteristics as described above for the single labeling (combinations: CB/TH, OTP/ISL1, CB/Go?
Gene_expression (one) of ISL1
11) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0
In addition, the expression of the territorial transcription factors ISL1 and NKX2.1 showed that this area is rich in cells that expressed ISL1 and almost totally lacks cells labeled for NKX2.1 (Figures 6C,D).
Gene_expression (expression) of ISL1
12) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0.43
In addition, the expression of the transcription factors ISL1 and NKX2.1 show a situation identical to that of the MeA in amphibians (González et al., 2002a,b; Moreno et al., 2008).
Gene_expression (expression) of ISL1 associated with amygdala
13) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0.28
We found that Brn3a is co-expressed with the pan-sensory transcription factor Islet1 at this stage, although the relative signals for the two proteins vary (Figure 1A).
Gene_expression (expressed) of Islet1
14) Confidence 0.14 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.14
Around the time of ganglion condensation and cell cycle exit, beginning at E9.5–10.5, nearly all sensory neurons at both spinal and cranial levels co-express the homeodomain transcription factors Brn3a and Islet1 [1,10].
Gene_expression (express) of Islet1 in sensory neurons associated with ganglion cysts
15) Confidence 0.12 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.71 Pain Relevance 0.09
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of isl-1 in TEK
16) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Gene_expression (expression) of Isl-1
17) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Neg (no) Gene_expression (expression) of isl-1 in TEK
18) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Consistent with this in vivo differentiation capacity, expression of core cardiac network mRNAs (GATA-4, Nkx2-5, isl-1, Mef2c, Hand2 and cardiac muscle actin) associated with skeletal and smooth muscle-specific mRNAs was detected in co-culture with embryonic cardiomyocytes.
Gene_expression (expression) of isl-1 in cardiomyocytes
19) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.16 Pain Relevance 0
While such data provide a one-time ‘snapshot’ of islet destruction, there is no clear knowledge of the precise cellular dynamics involved in this process.
Gene_expression (destruction) of islet
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009738 Disease Relevance 0.46 Pain Relevance 0.07

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