INT203445

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.93
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hes7) DNA binding (Hes7) transcription factor binding (Hes7)
Anatomy Link Frequency
cranial 1
ventricular zone 1
Hes7 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 291 98.44 Very High Very High Very High
nociceptor 96 92.04 High High
Central nervous system 12 88.16 High High
Pain 7 75.32 Quite High
medulla 5 71.00 Quite High
Spinal cord 9 70.44 Quite High
Neuropeptide 14 36.56 Quite Low
calcitonin gene related peptide 33 5.00 Very Low Very Low Very Low
mu opioid receptor 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 18 99.58 Very High Very High Very High
Repression 26 99.24 Very High Very High Very High
Cancer 75 99.04 Very High Very High Very High
Ganglion Cysts 325 98.44 Very High Very High Very High
Targeted Disruption 147 93.68 High High
Medulloblastoma 7 80.56 Quite High
Toxicity 1 78.80 Quite High
Pain 10 75.32 Quite High
Herpes Simplex Virus 3 71.12 Quite High
Recurrence 1 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice, the proneural bHLH factors Ngn1 and Ngn2 are expressed transiently from embryonic day 8.5 in cranial sensory precursors and have been shown to have a crucial role in neurogenesis [7-9].
Gene_expression (expressed) of bHLH in cranial associated with neurodegenerative disease
1) Confidence 0.03 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.71 Pain Relevance 0.12
In the DRG and TG, Brn3a facilitates the progression of sensory development by terminating the expression of neurogenic bHLH factors by direct repression [13,14], and a similar role has been described for Islet1 [15], defining one common function for these pan-sensory factors.
Gene_expression (expression) of bHLH associated with trigeminal ganglion and repression
2) Confidence 0.02 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 0.28
Sensory neurogenesis is dependent on the expression of the basic helix-loop-helix (bHLH) transcription factors Neurog1 and Neurog2 [4,5].
Gene_expression (expression) of bHLH associated with neurodegenerative disease
3) Confidence 0.02 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.54
However, direct regulation has been demonstrated only for bHLH transcription factors that are expressed early in sensory neurogenesis and subsequently repressed by Brn3a [14], and a direct transcriptional activator function has not been demonstrated for Brn3a in vivo.
Gene_expression (expressed) of bHLH associated with neurodegenerative disease
4) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 0.03
Persistent expression of bHLH HES1, the principal Notch-responsive gene, prevents both migration of neural progenitor cells out of the ventricular zone and expression of neuronal markers [21].
Gene_expression (expression) of bHLH in ventricular zone
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.82 Pain Relevance 0

General Comments

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