INT20345

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1981
Last Reported 2011
Negated 6
Speculated 3
Reported most in Abstract
Documents 136
Total Number 142
Disease Relevance 56.41
Pain Relevance 46.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
hypothalamus 8
plasma 6
brain 4
CCD 4
Leydig cells 3
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 107 100.00 Very High Very High Very High
cerebral cortex 36 100.00 Very High Very High Very High
Dynorphin 24 100.00 Very High Very High Very High
Nucleus accumbens 14 100.00 Very High Very High Very High
opioid receptor 36 99.98 Very High Very High Very High
dexamethasone 36 99.92 Very High Very High Very High
agonist 95 99.84 Very High Very High Very High
Central grey 59 99.84 Very High Very High Very High
Acupuncture 9 99.84 Very High Very High Very High
antagonist 84 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 683 100.00 Very High Very High Very High
Hyperinsulinism 4 100.00 Very High Very High Very High
Insulin Resistance 1 100.00 Very High Very High Very High
Influenza Virus Infection 276 99.84 Very High Very High Very High
Urological Neuroanatomy 129 99.84 Very High Very High Very High
Avian Sarcoma 10 99.84 Very High Very High Very High
Hemorrhage 8 99.80 Very High Very High Very High
Pain 79 99.74 Very High Very High Very High
Apoptosis 110 99.70 Very High Very High Very High
Ganglion Cysts 168 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, the DBI mRNA expressions in the CA1 region of the hippocampus (CA1), ventral tagmental area (VTA), nucleus accumbens (NAc) and amygdala (AMG) were positively correlated to CPP during the periods from withdrawal for 3 days to withdrawal for 6 days.
Gene_expression (expressions) of DBI mRNA in hippocampus associated with nucleus accumbens, hippocampus, withdrawal and amygdala
1) Confidence 0.78 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.16 Pain Relevance 0.93
Withdrawal for 3 days caused significant physical signs and further increased the DBI mRNA expression.
Gene_expression (expression) of DBI mRNA associated with withdrawal
2) Confidence 0.78 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.17 Pain Relevance 0.90
We found that chronic morphine treatment enabled CPP and increased the DBI mRNA expression in crucial brain regions of addiction.
Gene_expression (expression) of DBI mRNA in brain associated with addiction and morphine
3) Confidence 0.78 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.18 Pain Relevance 0.83
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Gene_expression (production) of Ep
4) Confidence 0.76 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Gene_expression (production) of Ep
5) Confidence 0.76 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
Prostaglandins have been shown to be involved in the regulation of renal function as well as erythropoietin (Ep) production.
Gene_expression (production) of Ep
6) Confidence 0.76 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.09 Pain Relevance 0.35
A similar second experiment was designed to determine if blood loss was the cause of altered Ep production.
Gene_expression (production) of Ep in blood associated with pressure volume 2 under development
7) Confidence 0.76 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.16 Pain Relevance 0.26
Antisense p21 ODN transfection of MDCK cells at 400 and 600 nM showed increased cell proliferation as compared to cells transfected with scrambled control ODN (Fig. 5b).
Gene_expression (transfection) of ODN in MDCK
8) Confidence 0.75 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.27 Pain Relevance 0
PF-3512676 (a synthetic CpG ODN) is also considered safe and effective in treating BCC [38], which presumably targets TLR 9.
Gene_expression (synthetic) of ODN associated with skin cancer
9) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.12 Pain Relevance 0.06
In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated.


Gene_expression (expression) of Dbi
10) Confidence 0.65 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020973 Disease Relevance 0.58 Pain Relevance 0.05
In another experiment, the brain content of beta-EP expressed as nanograms per region, increased from 12.6 +/- 0.29 to 14.7 +/- 0.33 in the hypothalamus, from 4.09 +/- 0.44 to 6.03 +/- 0.34 in the midbrain, and from 0.93 +/- 0.11 to 1.32 +/- 0.06 ng in the amygdala at 16-17 days of gestation compared with that in nonpregnant controls (P less than 0.01).
Gene_expression (expressed) of beta-EP in brain associated with midbrain and amygdala
11) Confidence 0.64 Published 1983 Journal Endocrinology Section Abstract Doc Link 6313328 Disease Relevance 0 Pain Relevance 0.22
The opioid peptide beta-endorphin (beta-EP), and the neurosteroid allopregnanolone are considered markers of neuroendocrine function and their synthesis and action is regulated by gonadal steroids.
Gene_expression (synthesis) of beta-EP in gonadal
12) Confidence 0.61 Published 2002 Journal Maturitas Section Abstract Doc Link 12443836 Disease Relevance 0.28 Pain Relevance 0.10
Both the DBI mRNA and CPP expression remained significantly high but physical signs were at control level in the animals withdrawal for 6 days.
Gene_expression (expression) of DBI mRNA associated with withdrawal
13) Confidence 0.60 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.17 Pain Relevance 0.90
No non-neuronal PBR expression is detected, unlike its putative endogenous ligand the diazepam binding inhibitor (DBI), which is expressed only in non-neuronal cells, including the satellite cells that surround DRG neurons.
Gene_expression (pressed o) of diazepam binding inhibitor in neurons associated with dorsal root ganglion
14) Confidence 0.58 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.81 Pain Relevance 0.46
No non-neuronal PBR expression is detected, unlike its putative endogenous ligand the diazepam binding inhibitor (DBI), which is expressed only in non-neuronal cells, including the satellite cells that surround DRG neurons.
Gene_expression (pressed o) of DBI in neurons associated with dorsal root ganglion
15) Confidence 0.58 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.80 Pain Relevance 0.45
No locomotor recovery was observed in the rats treated with the EphA4-antisense ODN.
Gene_expression (antisense) of ODN
16) Confidence 0.58 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16959251 Disease Relevance 0.79 Pain Relevance 0.56
RESULTS: Intrathecal injection of U0126 or ERK antisense ODN significantly attenuated CCI-induced mechanical allodynia and thermal hyperalgesia.
Gene_expression (antisense) of ODN
17) Confidence 0.58 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15960884 Disease Relevance 0.13 Pain Relevance 0
CpG ODNs have been synthesized using either a phosphodiester, phosphorothioate or a mixed DNA backbone with the phosphorothioate backbone rendering the CpG ODN more resistant to nucleases [96], extending the plasma half-life from about 5 min to 35–50 h, although a biphasic plasma elimination profile was observed [97], and lowering the dosage required for activity [91].
Gene_expression (synthesized) of ODN in plasma
18) Confidence 0.58 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0 Pain Relevance 0.23
-injected beta-EP may have contributed to the measured plasma i.r. beta-EP, a nonimmunoreactive analog (Des-Asn20-beta c-EP) was used to assess the change in plasma i.r. beta-EP. 5 microgram of DES-Asn20-beta c-EP injected i.v.t. caused increases in plasma i.r. beta-EP and CS, as well as a 40% reduction in pituitary i.r. beta-EP.
Gene_expression (used) of beta-EP in plasma
19) Confidence 0.57 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6270585 Disease Relevance 0 Pain Relevance 0.22
The present study examines the influence of destruction of the medio-basal arcuate hypothalamus (MBH), the primary site of synthesis of central pools of beta-endorphin (beta-EP), upon the aversive properties of naloxone in a conditioned place preference paradigm.
Gene_expression (synthesis) of beta-EP in MBH associated with narcan
20) Confidence 0.53 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2863837 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox