INT203460

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Crebbp (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 66 61.80 Quite High
Spinal cord 3 31.28 Quite Low
withdrawal 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 98.72 Very High Very High Very High
Targeted Disruption 18 75.96 Quite High
Ganglion Cysts 70 61.80 Quite High
Breast Cancer 14 57.44 Quite High
Prostate Cancer 40 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Ovarian Cancer 4 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast with our results, Comuzzi et al. have suggested that CBP expression is down-regulated after treating LNCaP cells with synthetic androgen methyltrienolone (R1881) for 48 hours at concentrations of 0.01 nM and 1 nM [29].
Negative_regulation (down) of Gene_expression (expression) of CBP
1) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.06 Pain Relevance 0
In contrast with our results, Comuzzi et al. have suggested that CBP expression is down-regulated after treating LNCaP cells with synthetic androgen methyltrienolone (R1881) for 48 hours at concentrations of 0.01 nM and 1 nM [29].
Negative_regulation (regulated) of Gene_expression (expression) of CBP
2) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.06 Pain Relevance 0
Transcriptional repressor functions have been described for the Hox genes [35], and there is evidence that Hox proteins can directly block the activity of the widely expressed histone acetyltransferase CBP-p300 [36].
Negative_regulation (block) of Gene_expression (expressed) of histone acetyltransferase CBP-p300
3) Confidence 0.02 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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