INT203463

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod4) nucleus (Neurod4) DNA binding (Neurod4)
Anatomy Link Frequency
spinal 1
Neurod4 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 207 99.28 Very High Very High Very High
Neurotransmitter 7 85.16 High High
Spinal cord 8 14.76 Low Low
superficial lamina 1 14.00 Low Low
nociceptor 32 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
medulla 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 15 100.00 Very High Very High Very High
Ganglion Cysts 225 99.28 Very High Very High Very High
Targeted Disruption 79 93.92 High High
Neurodegenerative Disease 15 81.80 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the most prominent distinguishing feature of sensory gene expression at spinal levels is the expression of multiple Hox genes, these factors are candidate mediators of this selective repression of NeuroD4 and Tcfap2b in the DRG.
Negative_regulation (repression) of NeuroD4 in spinal associated with repression
1) Confidence 0.56 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.68 Pain Relevance 0.06
However, in recent studies we have used locus-ChIP to demonstrate that Brn3a is a direct repressor of NeuroD1 and NeuroD4 in the embryonic TG [[27] in press], as well as a negative modulator of its own expression [32,33].
Negative_regulation (repressor) of NeuroD4 associated with trigeminal ganglion
2) Confidence 0.18 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.54 Pain Relevance 0.20
This group contains many transcription factors, including the known directly repressed targets Neurod1 and Neurod4 [14].
Negative_regulation (repressed) of Neurod4
3) Confidence 0.15 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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