INT203465

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Id1) cytoplasm (Id1)
Id1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 66 29.36 Quite Low
Neuropeptide 2 26.00 Quite Low
GABA receptor 1 24.92 Low Low
Somatostatin 3 23.44 Low Low
Serotonin 1 21.40 Low Low
gABA 2 20.04 Low Low
Glutamate receptor 1 18.84 Low Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 87.96 High High
Syndrome 28 60.92 Quite High
Rupture 2 58.36 Quite High
Adhesions 1 40.64 Quite Low
Brain Hemorrhage 2 39.80 Quite Low
Cleidocranial Dysplasia 2 37.44 Quite Low
Neurodegenerative Disease 6 36.92 Quite Low
Disease 12 36.32 Quite Low
Brain Stem Infarctions 2 34.96 Quite Low
Nociception 1 32.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Goumans et al. revealed that the inhibitor of DNA binding 1 (ID-1), a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors, is a specific downstream signal of ALK-1, whereas the proteinase inhibitor plasminogen activator inhibitor-1 (PAI-1) is induced by ALK-5 activation [68].
Negative_regulation (inhibitor) of DNA binding 1
1) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.23 Pain Relevance 0
Goumans et al. revealed that the inhibitor of DNA binding 1 (ID-1), a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors, is a specific downstream signal of ALK-1, whereas the proteinase inhibitor plasminogen activator inhibitor-1 (PAI-1) is induced by ALK-5 activation [68].
Negative_regulation (inhibitor) of ID-1
2) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.23 Pain Relevance 0
In contrast, specific bHLH genes, including those encoding NeuroD1, NeuroD6, Msc, and Nhlh2, were increased, and, perhaps consistent with this, the inhibitory bHLH factor Id1, which can act to oppose the action of neurogenic bHLH genes, was decreased.
Negative_regulation (decreased) of factor Id1
3) Confidence 0.04 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.22 Pain Relevance 0

General Comments

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