INT203467

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod4) nucleus (Neurod4) DNA binding (Neurod4)
Anatomy Link Frequency
spinal 1
Neurod4 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 282 99.24 Very High Very High Very High
Neurotransmitter 8 66.80 Quite High
mu opioid receptor 8 52.00 Quite High
calcitonin gene related peptide 22 47.92 Quite Low
nociceptor 64 27.92 Quite Low
substance P 6 13.44 Low Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 122 99.60 Very High Very High Very High
Ganglion Cysts 310 99.24 Very High Very High Very High
Repression 22 97.36 Very High Very High Very High
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failure of DRG neurons to increase NeuroD4 and Tcfap2b expression in Brn3a knockout ganglia suggests that a redundant mechanism of repression exists for these genes at spinal but not cranial levels.
Gene_expression (expression) of NeuroD4 in spinal associated with targeted disruption and repression
1) Confidence 0.74 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.68 Pain Relevance 0.11
The primer pairs used for locus-ChIP assays of the NeuroD4, Msc, Tcfap2b and Gata3 loci appear in additional file 5.
Gene_expression (assays) of NeuroD4
2) Confidence 0.65 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0 Pain Relevance 0
Brn3a has previously been shown to directly repress the expression of Neurod1 and Neurod4 [14] but an activator function has, to date, only been demonstrated in cell transfection models [21,29].
Gene_expression (expression) of Neurod4
3) Confidence 0.61 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.21
Prior work has shown that Brn3a is necessary to terminate the expression of early neurogenic transcription factors such as Neurod1 and Neurod4 in the developing TG.
Gene_expression (expression) of Neurod4 associated with trigeminal ganglion
4) Confidence 0.54 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.16

General Comments

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