INT20347

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.91
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PF4) extracellular region (PF4)
Anatomy Link Frequency
platelet 3
plasma 2
PF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 100.00 Very High Very High Very High
aspirin 4 98.84 Very High Very High Very High
cytokine 203 98.32 Very High Very High Very High
Angina 11 95.20 Very High Very High Very High
Pain 2 89.44 High High
depression 1 84.76 Quite High
chemokine 7 64.92 Quite High
Chronic pancreatitis 1 61.24 Quite High
Inflammation 22 53.04 Quite High
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 6 98.36 Very High Very High Very High
Cv General 3 Under Development 11 95.20 Very High Very High Very High
Thrombosis Related Under Development 2 92.08 High High
Pain 2 89.44 High High
Myelodysplastic Syndromes 6 89.32 High High
Pathologic Constriction 2 85.92 High High
Depression 1 84.76 Quite High
Toxicity 92 82.60 Quite High
Thrombosis 1 76.56 Quite High
Acute Coronary Syndrome 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum thromboxane B2, plasma beta-thromboglobulin, and platelet factor 4 were all temporarily increased in the group with intermediate coronary syndrome (p less than 0.01), whereas measurements in patients with progressive angina were not significantly different from the controls.
Positive_regulation (increased) of platelet factor 4 in platelet associated with angina and syndrome
1) Confidence 0.67 Published 1990 Journal Circulation Section Abstract Doc Link 2136815 Disease Relevance 1.17 Pain Relevance 0.77
Because hyperaggregability of platelets was demonstrated by an ex vivo platelet aggregation assay and by elevated plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4), antiplatelet therapy with aspirin and ticlopidine and cytoreduction therapy with hydroxyurea were started.
Positive_regulation (elevated) of PF4 in plasma associated with aspirin
2) Confidence 0.47 Published 2003 Journal Angiology Section Abstract Doc Link 12934770 Disease Relevance 0.59 Pain Relevance 0.22
Because hyperaggregability of platelets was demonstrated by an ex vivo platelet aggregation assay and by elevated plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4), antiplatelet therapy with aspirin and ticlopidine and cytoreduction therapy with hydroxyurea were started.
Positive_regulation (elevated) of platelet factor 4 in plasma associated with aspirin
3) Confidence 0.41 Published 2003 Journal Angiology Section Abstract Doc Link 12934770 Disease Relevance 0.59 Pain Relevance 0.22
Platelet activation was confirmed by a significant increase (P less than 0.05) in serotonin, platelet factor 4, and thromboxane B2 at almost all concentrations of HPF.
Positive_regulation (increase) of platelet factor 4 in Platelet associated with serotonin
4) Confidence 0.28 Published 1984 Journal J. Surg. Res. Section Abstract Doc Link 6482425 Disease Relevance 0.12 Pain Relevance 0.15
and platelet factor 4 (PF4)/CXCL4 are stored in secretory vesicles (in this case platelet granules) for immediate release upon cell activation.
Positive_regulation (stored) of CXCL4 in platelet
5) Confidence 0.23 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.44 Pain Relevance 0.36

General Comments

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