INT203489

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.33
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
ganglia 2
DRG 2
optic nerve 2
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 282 99.48 Very High Very High Very High
nociceptor 64 79.08 Quite High
Central nervous system 14 74.96 Quite High
anesthesia 6 46.68 Quite Low
Spinal cord 10 41.48 Quite Low
superficial lamina 2 40.72 Quite Low
calcitonin gene related peptide 22 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 123 99.96 Very High Very High Very High
Ganglion Cysts 321 99.48 Very High Very High Very High
Optic Nerve Injuries 4 95.62 Very High Very High Very High
Repression 22 73.68 Quite High
Ocular Hypertension 103 50.00 Quite Low
Neurodegenerative Disease 19 5.00 Very Low Very Low Very Low
Death 13 5.00 Very Low Very Low Very Low
Glaucoma 13 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.



Positive_regulation (upstream) of Gene_expression (acts) of Brn3a
1) Confidence 0.49 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.28
In mice lacking the POU-domain transcription factor Brn3a, the DRG and TG exhibit many common changes in gene expression, but a subset of Brn3a target genes show increased expression only in the TG.
Positive_regulation (increased) of Gene_expression (expression) of Brn3a in DRG associated with trigeminal ganglion
2) Confidence 0.45 Published 2007 Journal Neural Develop Section Abstract Doc Link PMC1796875 Disease Relevance 0.63 Pain Relevance 0.35
Because the direct effects of VP16-Brn3a result only in gene activation, the decreased expression of any gene is presumed to be an indirect effect.
Positive_regulation (effects) of Gene_expression (effects) of VP16-Brn3a
3) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.08
Thus, in the case of these genes with increased expression in the Brn3a knockout, H3 acetylation appears to reveal a latent state of potential expression, which is normally repressed by Brn3a or its downstream effectors, and de-repressed in Brn3a knockout ganglia.
Positive_regulation (increased) of Gene_expression (expression) of Brn3a in ganglia associated with targeted disruption
4) Confidence 0.43 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.60 Pain Relevance 0.13
Moreover, two to three days after optic nerve injury, there is an important decrease in the expression of the protein (as observed by western blotting and immunohistofluorescence) [51]; thus, an indirect way to examine the physiologic functional properties of RGCs is to examine their Brn3a expression.
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of Brn3a in optic nerve associated with optic nerve injuries
5) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.10 Pain Relevance 0

General Comments

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