INT203490

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 19
Total Number 46
Disease Relevance 27.56
Pain Relevance 12.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 15
ganglia 4
muscles 2
nervous system 2
embryos 1
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 935 100.00 Very High Very High Very High
trigeminal ganglion 2183 99.96 Very High Very High Very High
Spinal cord 229 99.60 Very High Very High Very High
Central nervous system 95 98.76 Very High Very High Very High
nociceptor 913 97.88 Very High Very High Very High
Peripheral nervous system 34 97.20 Very High Very High Very High
Neuropeptide 148 96.56 Very High Very High Very High
Acute pain 28 91.28 High High
calcitonin gene related peptide 308 84.36 Quite High
Serotonin 57 80.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3436 100.00 Very High Very High Very High
Targeted Disruption 1511 100.00 Very High Very High Very High
Sprains And Strains 34 99.80 Very High Very High Very High
Neurodegenerative Disease 158 99.60 Very High Very High Very High
Nociception 289 99.20 Very High Very High Very High
Death 90 97.72 Very High Very High Very High
Repression 251 96.08 Very High Very High Very High
Starvation 17 93.52 High High
Pain 85 91.28 High High
Apoptosis 34 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-gal mice revealed the expression of Runx1 and Runx3 in the nervous system in more detail [16,21,22].
Gene_expression (expression) of Runx3 in nervous system
1) Confidence 0.76 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.69 Pain Relevance 0.31
Expression of Runx1 and Runx3 in the nervous system
Gene_expression (Expression) of Runx3 in nervous system
2) Confidence 0.76 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.94 Pain Relevance 0.21
Ectopic expression of Runx3 is sufficient to drive axons from the dorsal to the ventral spinal cord, indicating that Runx3 per se has instructive roles in central axon targeting in DRG neurons.
Gene_expression (expression) of Runx3 in neurons associated with dorsal root ganglion and spinal cord
3) Confidence 0.76 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.75 Pain Relevance 0.50
First, the role of Runx3 in the neurotrophin receptor phenotype was shown by Arber and her colleagues [25], who thoroughly compared neurotrophin receptor synthesis in mouse strains in which Runx3 had been disrupted or expressed ectopically.
Gene_expression (expressed) of Runx3 associated with sprains and strains
4) Confidence 0.76 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.20 Pain Relevance 0.46
In control TG, Runx3 expression follows TrkC by one developmental day.
Gene_expression (expression) of Runx3 associated with trigeminal ganglion
5) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.63 Pain Relevance 0.47
In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors.
Gene_expression (expression) of Runx3 in neurons associated with nociceptor
6) Confidence 0.74 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.36
E13.5 was chosen for these assays, 1 to 2 days after the initiation of Runx3 expression, because we reasoned that at this time point regulators of Runx3 expression would still be bound to their targets.
Gene_expression (expression) of Runx3
7) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.08
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Gene_expression (expressing) of Runx3 in ganglia
8) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
This suggests that Runx1 promotes TrkC expression in late-developing cutaneous neurons in Runx3 knockouts, but not in Brn3a-/- ganglia in which both Runx1 and Runx3 expression are severely attenuated.


Gene_expression (expression) of Runx3 in neurons
9) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.36 Pain Relevance 0.73
In Brn3a-/- TG, TrkC expression is initiated normally, although Runx3 is never expressed, indicating that Runx3 is necessary for the maintenance but not the onset of TrkC expression, consistent with prior results in Runx3-/- embryos [34].
Neg (never) Gene_expression (expressed) of Runx3 in embryos associated with trigeminal ganglion
10) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.64 Pain Relevance 0.47
In Brn3a-/- embryos, TrkB- and TrkC-expressing neurons do not appropriately segregate into distinct populations, and Runx3 expression is not initiated (Figure 4F, H).
Gene_expression (expression) of Runx3 in neurons
11) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.25 Pain Relevance 0.17
Brn3a directly regulates Runx3 expression
Gene_expression (expression) of Runx3
12) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.36
During embryogenesis, Brn3a is required to initiate normal expression of the fate selector genes Runx3 and Runx1.
Gene_expression (expression) of Runx3
13) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.57 Pain Relevance 0.40
Together these data suggest that permitting the initiation of Runx3 expression is one of the primary roles of Brn3a.
Gene_expression (expression) of Runx3
14) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.28 Pain Relevance 0.15
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Gene_expression (expression) of Runx3
15) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.78 Pain Relevance 0.57
We next looked at the timing of the expression of TrkC and Runx3 markers in Brn3a-/- and control embryos to determine at what point in the development of these neurons Brn3a is required.
Gene_expression (expression) of Runx3 in neurons
16) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.70 Pain Relevance 0.52
E13.5 was chosen for these assays, 1 to 2 days after the initiation of Runx3 expression, because we reasoned that at this time point regulators of Runx3 expression would still be bound to their targets.
Gene_expression (expression) of Runx3
17) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.15 Pain Relevance 0.08
The Brn3a-/- TG exhibits a profound decrease in the expression of both Runx3 and Runx1, and failure to appropriately activate Runx expression can account for much of the early developmental phenotype of the Brn3a-/- TG.
Gene_expression (expression) of Runx3 associated with trigeminal ganglion
18) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.43
Runx3 is expressed in the trigeminal at this stage, and its expression pattern is nearly congruent with that of TrkC (Figure 4G).
Gene_expression (expressed) of Runx3
19) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.20 Pain Relevance 0.19
In contrast, Runx3 is not expressed at this stage in either genotype (Figure 4C, D).
Neg (not) Gene_expression (expressed) of Runx3
20) Confidence 0.74 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.33 Pain Relevance 0.27

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