INT203491

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 36.05
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Anatomy Link Frequency
TAF 2
HGF 2
VSM 1
cranial 1
bone marrow 1
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 161 98.40 Very High Very High Very High
trigeminal ganglion 198 94.16 High High
metalloproteinase 60 92.56 High High
imagery 184 90.40 High High
addiction 14 84.24 Quite High
cva 9 79.36 Quite High
ischemia 13 78.76 Quite High
Inflammation 98 69.20 Quite High
Central nervous system 33 67.52 Quite High
rheumatoid arthritis 71 58.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 3974 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 182 99.70 Very High Very High Very High
Osteogenic Sarcomas 448 99.12 Very High Very High Very High
Disease 117 99.08 Very High Very High Very High
Severe Combined Immunodeficiency 115 98.76 Very High Very High Very High
Lymphatic System Cancer 682 98.68 Very High Very High Very High
Obesity 144 98.56 Very High Very High Very High
Necrosis 96 98.48 Very High Very High Very High
Sprains And Strains 34 97.04 Very High Very High Very High
Epstein-barr Virus 55 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primer pairs used for locus-ChIP assays of the NeuroD4, Msc, Tcfap2b and Gata3 loci appear in additional file 5.
Gene_expression (assays) of Msc
1) Confidence 0.64 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0 Pain Relevance 0
The Msc gene is also normally silent, but it exhibits increased expression at both cranial and spinal levels in Brn3a null mice, and is accordingly H3 acetylated in both the DRG and TG.
Gene_expression (silent) of Msc in spinal associated with trigeminal ganglion
2) Confidence 0.64 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.64 Pain Relevance 0.16
As shown in Figure 4C, it should also be noticed that a significant (p<0.05) increase of the release of IL-8 and VEGF, with respect to MSC alone, was observed both in MSC/SKW6.4 as well as in MSC/BJAB co-cultures.


Gene_expression (/) of MSC
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.41 Pain Relevance 0.11
Of particular interest was the finding that mice co-injected with BJAB+MSC showed several intra-tumoral foci of necrosis (Figure 3B), and BJAB cell sheets with foci of necrosis were often coincident with areas containing ?
Gene_expression (injected) of MSC associated with necrosis
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.91 Pain Relevance 0.04
Intra-peritoneal (i.p.) injection of MSC (4 days after i.p. injection of lymphoma cells) significantly increased the overall survival at an optimal MSC?
Gene_expression (injection) of MSC associated with lymphatic system cancer
5) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886845 Disease Relevance 1.61 Pain Relevance 0.03
The injection of MSC delayed the development of the peritoneal tumoral masses of the NHL xenografts, and at necroscopic analysis, tumor specimens developed in the absence or presence of MSC showed significant histological differences, which can be recapitulated as follow: while BJAB- and/or SKW6.4-derived peritoneal masses showed the typical faint capillary network also described in human NHL [27], the presence of MSC promoted a diffuse increase in ?
Gene_expression (injection) of MSC in capillary associated with lymphatic system cancer and cancer
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 1.25 Pain Relevance 0
Of interest, the ability of MSC cultures of secreting high levels of angiogenic cytokines, such as VEGF, IL-8, angiogenin and CCL2, was significantly (p<0.01) enhanced by the concomitant presence of lymphoma cells.
Gene_expression (cultures) of MSC associated with lymphatic system cancer and cytokine
7) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.81 Pain Relevance 0.09
As expected, MSC produced significant levels of several pro-angiogenic cytokines, some of which (angiogenin, IL-8, CCL2 and VEGF) were significantly up-regulated by the concomitant presence of SKW6.4 cells (Figure 4B).
Gene_expression (produced) of MSC associated with cytokine
8) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.72 Pain Relevance 0.16
The effect of BM-MSC was analyzed in two in vivo models of disseminated non-Hodgkin's lymphomas with an indolent (EBV?
Spec (analyzed) Gene_expression (analyzed) of MSC in MSC associated with lymphatic system cancer and epstein-barr virus
9) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886845 Disease Relevance 1.34 Pain Relevance 0
The major finding of the present study is that a single MSC injection, at MSC?
Gene_expression (injection) of MSC
10) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 1.36 Pain Relevance 0
The major finding of the present study is that a single MSC injection, at MSC?
Gene_expression (injection) of MSC
11) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 1.36 Pain Relevance 0
On the other hand, regarding their potential therapeutic use in neoplastic diseases, some studies have suggested that adoptively transferred MSC could favor tumor engraftment and progression in vivo [9], [12], [15].
Gene_expression (transferred) of MSC associated with cancer and disease
12) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.79 Pain Relevance 0
As expected, on day 1, fluorescence was confined to endothelial cells, while MSC were completely negative.
Neg (negative) Gene_expression (negative) of MSC in endothelial cells
13) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.26 Pain Relevance 0
We demonstrate that under long-term tumor conditioning in vitro, MSC express TAF–like proteins.
Gene_expression (express) of MSC in TAF associated with cancer
14) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2661372 Disease Relevance 0.87 Pain Relevance 0.10
On the basis of our in vitro tumor growth assay data, we conclude that the MSC produced paracrine factors HGF, FGF, TGF-?
Gene_expression (produced) of MSC in HGF associated with cancer
15) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.60 Pain Relevance 0
Control mice were sacrificed for IHC comparison to the Skov-3/MSC 50?
Gene_expression (/) of MSC
16) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.29 Pain Relevance 0.03
In our admixed Skov-3/MSC tumors, IHC staining revealed elaborate looped and branched pattern arrangement of both ?
Gene_expression (tumors) of MSC associated with cancer
17) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.97 Pain Relevance 0
Our in vitro studies which mimic ischemic conditions show increased tPA and PAI-1 expression in OGD astrocytes, and that MSC-astrocyte co-culture concomitantly decreased the PAI-1 expression and increased tPA activity in astrocytes.
Gene_expression (expression) of MSC in astrocytes
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.94 Pain Relevance 0.08
The mouse MSC populations were analyzed for the following surface antigens for phenotypic characterization: CD29 (>90%), CD44 (>80%) and CD105 (>80%) and were free of hematopoietic cell phenotype CD11b (<1%), CD34 (<1%), and CD45 (<1%).
Spec (analyzed) Gene_expression (populations) of MSC in hematopoietic cell
19) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.36 Pain Relevance 0.09
While MSC do not typically express these markers, the expression of all three proteins was evident once the MSC were within the tumor microenvironment.
Neg (not) Gene_expression (express) of MSC associated with cancer
20) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.08 Pain Relevance 0

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