INT203498

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.29
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
embryos 3
ganglia 2
spinal 1
cranial 1
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 564 99.84 Very High Very High Very High
nociceptor 128 87.52 High High
Neuropeptide 24 46.56 Quite Low
GABA receptor 4 45.48 Quite Low
Somatostatin 24 44.00 Quite Low
Serotonin 12 41.96 Quite Low
gABA 8 40.60 Quite Low
Glutamate receptor 4 39.40 Quite Low
Neurotransmitter 16 36.00 Quite Low
5HT 4 20.32 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 620 99.84 Very High Very High Very High
Targeted Disruption 244 98.64 Very High Very High Very High
Adhesions 4 61.20 Quite High
Repression 44 58.04 Quite High
Neurodegenerative Disease 36 57.48 Quite High
Nociception 16 52.84 Quite High
Pain 16 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the generation of Brn3a+/+ and Brn3a-/- TG samples, Brn3a heterozygote mice were mated and the embryos were harvested at E13.5.
Localization (generation) of Brn3a in embryos associated with trigeminal ganglion
1) Confidence 0.73 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.42 Pain Relevance 0.09
The majority of sites tested gave ChIP enrichment values of two-fold or less relative to the Alb locus, indicating that these sites are probably not occupied by Brn3a in vivo.
Neg (not) Localization (occupied) of Brn3a
2) Confidence 0.73 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.06 Pain Relevance 0.03
In transgenic embryos expressing a Brn3a-VP16 dominant transactivator, Runx3 mRNA expression is increased, suggesting that it is a direct regulatory target of Brn3a.
Localization (target) of Brn3a in embryos associated with targeted disruption
3) Confidence 0.73 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.51 Pain Relevance 0.31
For the generation of Brn3a+/+ and Brn3a-/- TG samples, Brn3a heterozygote mice were mated and the embryos were harvested at E13.5.
Localization (generation) of Brn3a in embryos associated with trigeminal ganglion
4) Confidence 0.73 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.42 Pain Relevance 0.09
Notably, deletion of Brn3a effectively resulted in a triple-knockout of the Pou4 homeodomain class, because Pou4f2 (Brn3b) expression is nearly eliminated, and Pou4f3 (Brn3c) expression is greatly reduced in Brn3a knockout ganglia.
Localization (deletion) of Brn3a in ganglia associated with targeted disruption
5) Confidence 0.73 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.36 Pain Relevance 0
The state of histone H3 acetylation of Brn3a target gene loci offers some insight into the underlying mechanism of the differential regulation of these targets at spinal and cranial levels.
Localization (acetylation) of Brn3a in spinal
6) Confidence 0.73 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.56 Pain Relevance 0.20
A subset of Brn3a targets are unique to the cranial sensory ganglia
Localization (targets) of Brn3a in ganglia
7) Confidence 0.73 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.40 Pain Relevance 0.14
The state of histone H3 acetylation of Brn3a target gene loci offers some insight into the underlying mechanism of the differential regulation of these targets at spinal and cranial levels.
Localization (acetylation) of Brn3a in cranial
8) Confidence 0.25 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.56 Pain Relevance 0.20

General Comments

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