INT203506

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 6.17
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
nociceptor 3
embryos 1
spinal 1
ganglia 1
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 741 99.84 Very High Very High Very High
calcitonin gene related peptide 99 99.50 Very High Very High Very High
Serotonin 19 99.40 Very High Very High Very High
nociceptor 288 97.92 Very High Very High Very High
mu opioid receptor 36 97.28 Very High Very High Very High
Acute pain 9 92.88 High High
substance P 27 88.88 High High
Somatostatin 30 84.40 Quite High
Pain 20 78.72 Quite High
Neuropeptide 38 77.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 411 99.96 Very High Very High Very High
Ganglion Cysts 835 99.84 Very High Very High Very High
Nociception 28 99.52 Very High Very High Very High
Repression 67 97.72 Very High Very High Very High
Pain 29 92.88 High High
Death 18 69.56 Quite High
Neurodegenerative Disease 33 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 9 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a is required for the expression of a battery of functional genes in differentiated nociceptors
Positive_regulation (required) of Brn3a in nociceptors associated with nociceptor
1) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.36 Pain Relevance 0.75
It is clear that Brn3a is not required for the initiation of TrkC expression because at E10.5 TrkC is expressed appropriately in Brn3a-/- embryos, and is co-expressed with TrkB in a pattern similar to the wild type (Figure 4B).
Neg (not) Positive_regulation (required) of Brn3a in embryos
2) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.42
The only mediator of nociception found to show a marked increase in expression in the Brn3a-/- TG was the serotonin receptor subunit Htr3a (Figure 3C), which, unlike other serotonin receptors, is a ligand gated ion channel that forms functional pentameric 5HTR3 complexes with itself or Htr3b subunits [43].
Positive_regulation (increase) of Brn3a associated with nociception, trigeminal ganglion and serotonin
3) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 1.06 Pain Relevance 0.84
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Positive_regulation (required) of Brn3a
4) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.79 Pain Relevance 0.63
Brn3a is required for the expression of a battery of Runx1-dependent nociceptor markers
Positive_regulation (required) of Brn3a in nociceptor associated with nociceptor
5) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.91
Brn3a is required for Runx1 expression and the segregation of TrkA/TrkB expression in nociceptor precursors
Positive_regulation (required) of Brn3a in nociceptor associated with nociceptor
6) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.23
Ichikawa et al. [17] have previously reported, consistent with the present study, that CGRP expression is minimally changed in the Brn3a-/- TG.
Positive_regulation (changed) of Brn3a associated with calcitonin gene related peptide and trigeminal ganglion
7) Confidence 0.49 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.75 Pain Relevance 0.62
Prior work has shown that Brn3a is necessary to terminate the expression of early neurogenic transcription factors such as Neurod1 and Neurod4 in the developing TG.
Positive_regulation (necessary) of Brn3a associated with trigeminal ganglion
8) Confidence 0.46 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.44 Pain Relevance 0.15
Islet1 was employed as a specific nuclear marker for sensory neurons because its expression does not change in Brn3a knockout ganglia.
Neg (not) Positive_regulation (change) of Brn3a in ganglia associated with targeted disruption
9) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.79 Pain Relevance 0.20
The failure of DRG neurons to increase NeuroD4 and Tcfap2b expression in Brn3a knockout ganglia suggests that a redundant mechanism of repression exists for these genes at spinal but not cranial levels.
Positive_regulation (increase) of Brn3a in spinal associated with targeted disruption and repression
10) Confidence 0.43 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.68 Pain Relevance 0.11
Pou4f1 is specifically upregulated in the dI4 and dI4LA populations of mutants [30].
Positive_regulation (upregulated) of Pou4f1
11) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox