INT203514

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f3) DNA binding (Pou4f3)
Anatomy Link Frequency
ganglia 4
Pou4f3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 4 40.52 Quite Low
GABA receptor 2 39.44 Quite Low
Somatostatin 6 37.96 Quite Low
Serotonin 2 35.92 Quite Low
gABA 4 34.56 Quite Low
Glutamate receptor 2 33.36 Quite Low
trigeminal ganglion 132 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 99.60 Very High Very High Very High
Adhesions 2 55.16 Quite High
Neurodegenerative Disease 12 51.44 Quite High
Nociception 2 46.80 Quite Low
Ganglion Cysts 140 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, deletion of Brn3a effectively resulted in a triple-knockout of the Pou4 homeodomain class, because Pou4f2 (Brn3b) expression is nearly eliminated, and Pou4f3 (Brn3c) expression is greatly reduced in Brn3a knockout ganglia.
Negative_regulation (reduced) of Gene_expression (expression) of Pou4f3 in ganglia associated with targeted disruption
1) Confidence 0.49 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.30 Pain Relevance 0
Notably, deletion of Brn3a effectively resulted in a triple-knockout of the Pou4 homeodomain class, because Pou4f2 (Brn3b) expression is nearly eliminated, and Pou4f3 (Brn3c) expression is greatly reduced in Brn3a knockout ganglia.
Negative_regulation (reduced) of Gene_expression (expression) of Brn3c in ganglia associated with targeted disruption
2) Confidence 0.36 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.30 Pain Relevance 0

General Comments

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