INT203568

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.61
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SKP2) cytosol (SKP2) nucleoplasm (SKP2)
Anatomy Link Frequency
blood 1
SKP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 98.40 Very High Very High Very High
Cannabinoid 24 94.32 High High
COX2 2 87.84 High High
agonist 66 50.00 Quite Low
Bile 4 42.44 Quite Low
isoflurane 8 23.84 Low Low
halothane 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 16 99.36 Very High Very High Very High
Toxicity 20 82.88 Quite High
Hepatocellular Cancer 16 82.40 Quite High
Bladder Cancer 4 76.32 Quite High
Nicotine Addiction 2 63.36 Quite High
Hepatotoxicity 18 58.20 Quite High
Obesity 138 54.08 Quite High
Stress 8 44.44 Quite Low
Body Weight 8 43.36 Quite Low
Breast Cancer 2 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase occurred through down-regulation of nuclear S-phase kinase-associated protein 2 (SKP2) [80].
Regulation (regulation) of SKP2
1) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.75 Pain Relevance 0.04
This increase occurred through down-regulation of nuclear S-phase kinase-associated protein 2 (SKP2) [80].
Regulation (regulation) of nuclear S-phase kinase-associated protein 2
2) Confidence 0.22 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.75 Pain Relevance 0.04
The optimal value of fLB was 0.0075 and the corresponding values of the blood/water (eq. (2)) and adipose/blood (eq. (4)) partition coefficients are listed in Table 4.


Regulation (value) of fLB in blood
3) Confidence 0.03 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.06 Pain Relevance 0.12
The optimal value of fLB was 0.0075.
Regulation (value) of fLB
4) Confidence 0.03 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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