INT203591

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) extracellular region (LAMB2) cell adhesion (LAMB2)
structural molecule activity (LAMB2) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
cleavage 3
PIK3CG (Homo sapiens)
LAMB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 100.00 Very High Very High Very High
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 5 98.58 Very High Very High Very High
Cancer 45 96.80 Very High Very High Very High
Reprotox - General 1 26 64.04 Quite High
Adenocarcinoma 1 58.60 Quite High
Metastasis 2 19.84 Low Low
Hypoxia 2 17.76 Low Low
Inflammatory Breast Neoplasms 8 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In melanoma cells, it has been reported that in the VM signaling cascade there is activation of phosphatidylinositol-3 kinase, which in turn promotes the activity of MMPs and cleavage of laminin 5?
Positive_regulation (activation) of phosphatidylinositol-3 kinase in cleavage Positive_regulation (promotes) of Protein_catabolism (cleavage) of laminin in cleavage associated with melanoma and metalloproteinase
1) Confidence 0.00 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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