INT2036

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Context Info
Confidence 0.77
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 42
Total Number 43
Disease Relevance 21.50
Pain Relevance 9.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
epithelium 3
Macrophages 2
BUC 2
brain 1
fibroblast 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 252 100.00 Very High Very High Very High
Inflammation 201 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
opioid receptor 5 99.84 Very High Very High Very High
sodium channel 246 99.76 Very High Very High Very High
Cannabinoid receptor 20 99.76 Very High Very High Very High
Neuropeptide 2 99.42 Very High Very High Very High
peptic ulcer disease 7 99.28 Very High Very High Very High
interstitial cystitis 25 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 225 100.00 Very High Very High Very High
Cystitis 6 99.96 Very High Very High Very High
Natriuresis 1 99.92 Very High Very High Very High
Reprotox - General 1 221 99.76 Very High Very High Very High
Cancer 476 99.68 Very High Very High Very High
Disease 135 99.28 Very High Very High Very High
Interstitial Cystitis 25 99.16 Very High Very High Very High
Ulcers 15 99.12 Very High Very High Very High
Fibrosis 45 99.10 Very High Very High Very High
Leukemia 10 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biotinylation of collagen and the growth factors allows immobilization of HBGF2 and EGF by high affinity binding of tetravalent avidin.
Localization (immobilization) of EGF
1) Confidence 0.77 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0
In the main part, EGF is tonically released from PCa cells, consistent with the effect of AG1478 alone, also, [46,47].
Localization (released) of EGF associated with reprotox - general 1
2) Confidence 0.75 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.76 Pain Relevance 0.55
METHODS: Caco-2 cells were serum-starved (48 h) and subsequently treated (48 h) with either serum-free media or EGF (10 ng/ml) +/- physiologic and noninjurious (as determined by LDH release) concentrations of aspirin, indomethacin, and ibuprofen.
Localization (treated) of EGF in Caco-2
3) Confidence 0.75 Published 1999 Journal J. Surg. Res. Section Body Doc Link 10357918 Disease Relevance 0.09 Pain Relevance 0
Treatment of IC BUC with heparin-binding epidermal growth factor-like growth factor (HB-EGF), previously shown to be secreted in lower amounts by IC BUC, significantly increased inward potassium current.
Localization (secreted) of EGF in BUC associated with interstitial cystitis
4) Confidence 0.74 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 1.01 Pain Relevance 1.05
EGF is secreted in higher amounts by IC BUC and is known to decrease Kir2.1 conductance by phosphorylation of Kir2.1.
Localization (secreted) of EGF in BUC associated with interstitial cystitis
5) Confidence 0.74 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 1.07 Pain Relevance 1.03
The effect of indomethacin on the secretion of human salivary epidermal growth factor.
Localization (secretion) of epidermal growth factor
6) Confidence 0.70 Published 1994 Journal Am. J. Gastroenterol. Section Title Doc Link 8273807 Disease Relevance 0.10 Pain Relevance 0.29
These data support our premise that one mechanism whereby NSAIDs may attenuate colonic neoplasia is by blocking EGF-induced Ca++ mobilization.
Localization (mobilization) of EGF-induced associated with cancer and cinod
7) Confidence 0.70 Published 2000 Journal J. Gastrointest. Surg. Section Abstract Doc Link 10675238 Disease Relevance 0.25 Pain Relevance 0.21
Twenty-four-hour urinary excretion of RIA-hEGF by normal adult males and females was 63.0 +/- 3.0 and 52.0 +/- 3.5 (mean +/- SE) micrograms/total vol, or 29.7 +/- 1.1 and 39.8 +/- 1.7 micrograms/g creatinine, respectively.
Localization (excretion) of hEGF
8) Confidence 0.69 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.12 Pain Relevance 0.06
The outcome of our studies let us suggest that EGF-like ligands released by opioid receptor stimulation utilize different EGF receptors to phosphorylate ERKs, while EGF utilizes type 1 receptors.
Localization (released) of EGF associated with opioid receptor
9) Confidence 0.69 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464054 Disease Relevance 0 Pain Relevance 0.43
If VGSC activity controlled the release of EGF (eg via vesicular trafficking), it could lead to the following positive feed-back: VGSC activity ?
Localization (release) of EGF associated with sodium channel
10) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.62 Pain Relevance 0.57
EGF release ?
Localization (release) of EGF
11) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.70 Pain Relevance 0.55
Epidermal growth factor inhibits gastric acid secretion and has a cytoprotective effect on the upper gastrointestinal tract.
Localization (secretion) of Epidermal growth factor in upper
12) Confidence 0.66 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2389722 Disease Relevance 0.35 Pain Relevance 0.14
An excellent linear correlation was observed between RIA-hEGF and creatinine concentrations in each urine sample for each subject, suggesting that RIA-hEGF concentration in a random urine sample provides a valid index of 24-h RIA-hEGF excretion.
Localization (excretion) of hEGF in urine
13) Confidence 0.64 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.45 Pain Relevance 0.15
There was no apparent diurnal or postprandial variation in urinary RIA-hEGF excretion by normal subjects.
Localization (excretion) of hEGF
14) Confidence 0.64 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.52 Pain Relevance 0.17
Adult males with active peptic ulcer disease appeared to have lower urinary RIA-hEGF excretion (22.9 +/- 2.6 micrograms/g creatinine) than normal men, but this was not significant (P greater than 0.05).
Localization (excretion) of hEGF associated with peptic ulcer disease and disease
15) Confidence 0.64 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.53 Pain Relevance 0.18
A variety of growth factors have been identified within the glandular epithelium and the luminal secretions by immunohistochemistry, including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and leukaemia inhibitory factor (LIF) [8].
Localization (secretions) of epidermal growth factor in epithelium associated with leukemia
16) Confidence 0.63 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.10 Pain Relevance 0
Recent evidence suggests the probable identity of hEGF and beta-urogastrone, a potent inhibitor of gastric acid secretion.
Localization (secretion) of hEGF
17) Confidence 0.61 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.49 Pain Relevance 0.17
A variety of growth factors have been identified within the glandular epithelium and the luminal secretions by immunohistochemistry, including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and leukaemia inhibitory factor (LIF) [8].
Localization (secretions) of EGF in epithelium associated with leukemia
18) Confidence 0.58 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.10 Pain Relevance 0
Finally, cetuximab may block the nuclear import of EGF-R, preventing activation of the DNA repair mechanism that protects cells from radiation- or chemotherapy-induced DNA damage [7-9].
Localization (import) of EGF-R
19) Confidence 0.48 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.56 Pain Relevance 0
Finally, cetuximab may block the nuclear import of EGF-R, preventing activation of the DNA repair mechanism that protects cells from radiation- or chemotherapy-induced DNA damage [7-9].
Localization (import) of EGF-R
20) Confidence 0.48 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.56 Pain Relevance 0

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