INT203612

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP2) cell adhesion (NRP2) plasma membrane (NRP2)
NRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 97.64 Very High Very High Very High
COX-2 inhibitor 6 81.16 Quite High
cytokine 3 51.72 Quite High
dorsal root ganglion 1 16.76 Low Low
Chronic low back pain 9 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 95.32 Very High Very High Very High
Cancer 46 82.96 Quite High
Apoptosis 7 76.92 Quite High
Repression 1 65.28 Quite High
Death 4 52.08 Quite High
Reprotox - General 1 26 50.00 Quite Low
Intervertebral Disk Degeneration 3 46.72 Quite Low
Ganglion Cysts 1 16.76 Low Low
Targeted Disruption 1 11.68 Low Low
Low Back Pain 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, as well as binding members of the PLX family the NRPs bind VEGF receptors to enhance VEGF165 activity suggesting they also play a role in regulating angiogenesis through the competitive inhibition of sema3A and VEGF against one another for overlapping binding sites on the NRP molecule [45,46].
Positive_regulation (enhance) of VEGF165
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.10 Pain Relevance 0.03
binding proteins, and upregulation of neuropilin 2 (a VEGF receptor).
Positive_regulation (upregulation) of neuropilin 2
2) Confidence 0.09 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.40 Pain Relevance 0.09

General Comments

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