INT203614

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES2) cytosol (PTGES2) mitochondrion (PTGES2)
Golgi apparatus (PTGES2) nucleus (PTGES2) DNA binding (PTGES2)
PTGES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 49.00 Quite Low
COX-2 inhibitor 6 32.52 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 80.12 Quite High
Death 3 76.64 Quite High
Reprotox - General 1 26 50.00 Quite Low
Cancer 45 34.32 Quite Low
Repression 1 16.64 Low Low
Inflammatory Breast Neoplasms 8 5.00 Very Low Very Low Very Low
Melanoma 5 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in the COX pathway, celecoxib treatment caused downregulation of phospholipase A2 receptor 1 and prostaglandin E synthase 2, which is consistent with our previous report in which PGE2 protein was shown to be significantly downregulated after celecoxib treatment [15,29].
Positive_regulation (caused) of Negative_regulation (downregulation) of E synthase 2
1) Confidence 0.07 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.30 Pain Relevance 0

General Comments

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