INT203616

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 18
Disease Relevance 12.62
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (CDKN1C) nucleus (CDKN1C) cell cycle (CDKN1C)
cytoplasm (CDKN1C)
Anatomy Link Frequency
joints 2
knee 2
ankle joints 1
foot 1
vastus lateralis 1
CDKN1C (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 51 92.48 High High
Central nervous system 68 63.84 Quite High
metalloproteinase 11 56.88 Quite High
Pain 17 43.16 Quite Low
COX-2 inhibitor 6 40.40 Quite Low
backache 17 37.24 Quite Low
Multiple sclerosis 17 11.88 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Beckwith-wiedemann Syndrome 1292 100.00 Very High Very High Very High
Aging 221 97.00 Very High Very High Very High
Stroke 68 94.44 High High
Body Weight 221 94.12 High High
Spinal Cord Injury 34 92.48 High High
Apoptosis 7 88.00 High High
Injury 34 86.16 High High
Death 3 84.52 Quite High
Reprotox - General 1 26 50.00 Quite Low
Pain 17 43.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, variability at the ankle increased with higher BWS levels, which correlates to the findings of Threlkeld et al. [47].
Positive_regulation (increased) of BWS in ankle associated with beckwith-wiedemann syndrome
1) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.94 Pain Relevance 0.04
Increased levels of BWS resulted in increased linear and nonlinear measures of joint kinematic variability.
Positive_regulation (Increased) of BWS in joint associated with beckwith-wiedemann syndrome
2) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.52 Pain Relevance 0.03
Overall our results refuted our first hypothesis showing that increased levels of BWS resulted in increased variability.
Positive_regulation (increased) of BWS associated with beckwith-wiedemann syndrome
3) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.77 Pain Relevance 0
In order to minimize the vest shifting up the torso with increased levels of BWS, air was hand-pumped into the right and left chambers of the vest until it was comfortably tight.
Positive_regulation (increased) of BWS associated with beckwith-wiedemann syndrome
4) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.42 Pain Relevance 0
It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.
Positive_regulation (increased) of BWS in angular associated with beckwith-wiedemann syndrome
5) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 1.03 Pain Relevance 0
Threlkeld et al. [47] also found minimal variability of the knee angle with increased BWS.
Positive_regulation (increased) of BWS in knee associated with beckwith-wiedemann syndrome
6) Confidence 0.60 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.80 Pain Relevance 0
The purpose of this study was to determine the kinematic variability of the lower extremities in young and elderly healthy females at changing levels of BWS during walking.
Positive_regulation (changing) of BWS associated with beckwith-wiedemann syndrome
7) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 1.17 Pain Relevance 0
Increased levels of BWS increased lower extremity kinematic variability.
Positive_regulation (Increased) of BWS in extremity associated with beckwith-wiedemann syndrome
8) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Abstract Doc Link PMC2564959 Disease Relevance 0.84 Pain Relevance 0
Therefore, the purpose of this study was to determine the kinematic variability of the lower extremities in young and elderly healthy females at changing levels of BWS during walking.
Positive_regulation (changing) of BWS associated with beckwith-wiedemann syndrome
9) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.67 Pain Relevance 0.03
It was reported that foot placement became unsteady and uncoordinated at higher levels of BWS.
Positive_regulation (levels) of BWS in foot associated with beckwith-wiedemann syndrome
10) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.88 Pain Relevance 0.05
Moreover, higher levels of BWS presented increased variability at all joints as found in both the linear and nonlinear measures utilized.


Positive_regulation (levels) of BWS in joints associated with beckwith-wiedemann syndrome
11) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Abstract Doc Link PMC2564959 Disease Relevance 0.84 Pain Relevance 0
It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.
Positive_regulation (increased) of BWS in hip associated with beckwith-wiedemann syndrome
12) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03
Finch et al. [61] and Hesse et al. [26] reported that with increased levels of BWS more weight was supported by the harness and there was decreased activity in the vastus lateralis, which is a muscle of the knee that is sensitive to limb loading.
Positive_regulation (increased) of BWS in vastus lateralis associated with beckwith-wiedemann syndrome
13) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.76 Pain Relevance 0
Earlier investigations [47,61] found that higher levels of BWS lifted the center of mass and as a result hip displacement decreased as there was less need for propelling the body forward during gait.
Positive_regulation (levels) of BWS in body associated with beckwith-wiedemann syndrome
14) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.45 Pain Relevance 0.03
This outcome was attributed by these authors to the balance component of gait being stressed at higher levels of BWS.
Positive_regulation (levels) of BWS associated with beckwith-wiedemann syndrome
15) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.65 Pain Relevance 0
Celecoxib also affected the cell cycle pathway by causing an upregulation of cyclin-dependent kinase inhibitors p57, p21 and kip2, and downregulation of cyclin F and cell division cycle associated 3 proteins.
Positive_regulation (upregulation) of p57
16) Confidence 0.19 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.33 Pain Relevance 0.03
It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.
Positive_regulation (increased) of BWS in knee associated with beckwith-wiedemann syndrome
17) Confidence 0.14 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03
It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.
Positive_regulation (increased) of BWS in ankle joints associated with beckwith-wiedemann syndrome
18) Confidence 0.14 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03

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