INT203646

Context Info Confidence 0.63 First Reported 2004 Last Reported 2010 Negated 6 Speculated 0 Reported most in Body Documents 26 Total Number 31 Disease Relevance 23.57 Pain Relevance 1.14

Golgi apparatus (STIP1) nucleus (STIP1) protein complex (STIP1) response to stress (STIP1) cytoplasm (STIP1)

Anatomy Link Frequency urine 5 stigma 3 uterine 1 intervertebral disc 1 STIP1 (Homo sapiens)

Pain Link Frequency Relevance Heat backache 8 96.56 Inflammation 78 90.24 Dysuria 6 87.40 pain pelvic 7 83.68 Pain 55 70.96 abdominal pain 27 50.80 metalloproteinase 6 5.00 Crohn's disease 6 5.00 cytokine 5 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat Infection 1271 100.00 Aging 62 100.00 Stress 15 100.00 Papillomavirus Infection 191 99.94 Intervertebral Disk Degeneration 1 99.00 Respiratory Tract Infection 64 98.74 Reprotox - General 1 7 98.60 Acquired Immune Deficiency Syndrome Or Hiv Infection 438 98.28 Anus Neoplasms 4 98.28 Confusion 24 98.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To calculate the treatment and sequelae costs averted by the interruption of STI transmission, we applied published estimates of the average lifetime cost per case of syphilis, gonorrhea, and chlamydia, as these estimates incorporate the probability and cost of STI treatment as well as the probability and cost of adverse sequelae in the absence of treatment.

Gene_expression (transmission) of STI associated with gonorrhea, chlamydia infection, trepenoma infection and infection

1) Confidence 0.63 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2426671 Disease Relevance 1.55 Pain Relevance 0

We assumed that each STI case treated prevents, on average, 0.5 cases of that STI in the population by interrupting the transmission of that STI.

Gene_expression (transmission) of STI associated with infection

2) Confidence 0.63 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2426671 Disease Relevance 1.50 Pain Relevance 0

In developing the formula for costs averted through the interruption of STI transmission, we excluded people treated for STIs as a result of partner notification, to reduce potential double-counting of the benefits of preventing STIs in partners of infected people treated for STIs.

Gene_expression (transmission) of STI associated with infection

3) Confidence 0.63 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2426671 Disease Relevance 2.61 Pain Relevance 0

Embarrassment associated with talking to peers and partners about STI testing

Gene_expression (testing) of STI

4) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.22 Pain Relevance 0

A minority of respondents indicated that they would not inform their partners about positive STI diagnoses so as to avoid having embarrassing confrontations with them.

Gene_expression (diagnoses) of positive STI

5) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.13 Pain Relevance 0

Shame and embarrassment associated with accessing STI testing facilities

Gene_expression (facilities) of STI

6) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0 Pain Relevance 0

Respondents who tested negative for an STI, or who tested positive for an STI that they felt had no particular stigmatizing connotations, usually felt proud that they had sought STI testing.

Neg (negative) Gene_expression (tested) of an STI

7) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0 Pain Relevance 0

Respondents who tested negative for an STI, or who tested positive for an STI that they felt had no particular stigmatizing connotations, usually felt proud that they had sought STI testing.

Gene_expression (testing) of STI

8) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0 Pain Relevance 0

Respondents who sought STI testing because they had had unprotected sex also felt anxious about their risk status.

Gene_expression (sought) of STI

9) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.43 Pain Relevance 0

While the MSM interviewed generally exhibited higher levels of STI-related knowledge and in many cases prior experiences with STIs, there were almost no indications that they had any dialogue or counseling with their attending physicians regarding STI prevention.

Gene_expression (interviewed) of STI-related associated with infection

10) Confidence 0.47 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 1.07 Pain Relevance 0

Interviewer: Didn't your doctor talk with you about your STI, or about the STI risks?

Gene_expression (risks) of STI

11) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.76 Pain Relevance 0.11

Interviewer: Do you have any idea how you got this STI?

Gene_expression (got) of STI

12) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.43 Pain Relevance 0.04

This was predominantly due to confusion they harbored following their clinical interaction regarding the consequences of their STI diagnosis such as the relationship between STIs and HIV/AIDS or infertility.

Gene_expression (diagnosis) of STI associated with reprotox - general 3, acquired immune deficiency syndrome or hiv infection, infection and confusion

13) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.85 Pain Relevance 0

Interviewer: Didn't your doctor talk with you about your STI, or about the STI risks?

Gene_expression (risks) of STI

14) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.76 Pain Relevance 0.11

Perceived stigma and the lack of counseling and support received not only appeared to impact the patient's knowledge and health, but also their ability to notify their partner(s) of their STI diagnosis, as suggested in the following excerpt:

Gene_expression (diagnosis) of STI in stigma

15) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.49 Pain Relevance 0.04

For example, we observed that female participants appeared to possess less STI-related knowledge and greater levels of perceived STI-related stigma than male participants, resulting in additional confusion and anxiety regarding whether to seek care.

Gene_expression (knowledge) of STI-related in stigma associated with anxiety disorder and confusion

16) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.31 Pain Relevance 0

While the MSM interviewed generally exhibited higher levels of STI-related knowledge and in many cases prior experiences with STIs, there were almost no indications that they had any dialogue or counseling with their attending physicians regarding STI prevention.

Neg (prevention) Gene_expression (prevention) of STI associated with infection

17) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.91 Pain Relevance 0

Interviewer: And do you have any idea how you got this STI?

Gene_expression (got) of STI

18) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.76 Pain Relevance 0.11

[MSM, 19 years old, with HPV] STI-related knowledge, fears and perceived stigma post-diagnosis

Gene_expression (knowledge) of STI-related in stigma associated with papillomavirus infection

19) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.54 Pain Relevance 0.10

The MSM we interviewed gave almost no indication that there had been any type of dialogue regarding STI prevention during their visit.

Neg (prevention) Gene_expression (prevention) of STI

20) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.66 Pain Relevance 0

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