INT203677

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (RCAN1) nucleus (RCAN1) DNA binding (RCAN1)
cytoplasm (RCAN1)
RCAN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 21 99.68 Very High Very High Very High
Cancer 97 98.96 Very High Very High Very High
Down Syndrome 2 89.84 High High
Apoptosis 17 50.00 Quite Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Female Infertility 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of RCAN1-4 significantly reduced the PROKR1 mediated induction of IL-11 mRNA expression at 8 h (Fig. 2B; P < 0.01) and protein secretion at 12 h (Fig. 2C; P < 0.05) compared with cells infected with the control empty virus.


Negative_regulation (reduced) of Gene_expression (Overexpression) of RCAN1
1) Confidence 0.39 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Negative_regulation (inhibits) of Gene_expression (overexpression) of RCAN1
2) Confidence 0.39 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
To verify the microarray results, we used quantitative real- time PCR, which confirmed that the expression of Psp, Pip and Csp1 was markedly diminished in the hyperoxia-exposed tumors (Table 2).


Negative_regulation (diminished) of Gene_expression (expression) of Csp1 associated with cancer and hyperoxia
3) Confidence 0.04 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1797183 Disease Relevance 1.15 Pain Relevance 0

General Comments

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