INT203687

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (H2afx) chromosome (H2afx) nucleus (H2afx)
enzyme binding (H2afx) cell cycle (H2afx) DNA binding (H2afx)
Anatomy Link Frequency
neurons 1
H2afx (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 48.16 Quite Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 147 98.96 Very High Very High Very High
Disease 156 98.76 Very High Very High Very High
Aging 18 98.04 Very High Very High Very High
Dyskinesias 3 84.76 Quite High
Chromosomal Instability 2 80.12 Quite High
Genetic Translocation 2 78.68 Quite High
Cancer 8 74.16 Quite High
Stress 21 71.12 Quite High
Pain 2 48.16 Quite Low
Infection 15 24.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The accumulation of phosphorylated histone H2AX (?
Positive_regulation (accumulation) of H2AX
1) Confidence 0.40 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.21 Pain Relevance 0
-H2AX was greatly increased by chrysotile treatment in MEF cells, which was inhibited by concurrent treatment with catalase.
Positive_regulation (increased) of H2AX
2) Confidence 0.40 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.37 Pain Relevance 0
H2AX was increased in Western blot analysis (Fig. 1 B).
Positive_regulation (increased) of H2AX
3) Confidence 0.27 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.29 Pain Relevance 0
S1 shows activation of H2AX and 53BP1 in the nuclei of striatal neurons of R6/2 mice.
Positive_regulation (activation) of H2AX in neurons
4) Confidence 0.27 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.23 Pain Relevance 0
H2AX increased moderately in normal and transgenic mice during aging (Fig. 1, A and B), whereas the ?
Positive_regulation (increased) of H2AX associated with targeted disruption and aging
5) Confidence 0.23 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.76 Pain Relevance 0

General Comments

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