INT203688

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.08
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) embryo development (Hmgcr)
Anatomy Link Frequency
heart 1
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 49 100.00 Very High Very High Very High
Inflammation 36 89.28 High High
Dopamine 2 83.80 Quite High
Arthritis 3 78.12 Quite High
abdominal pain 2 77.68 Quite High
headache 3 76.60 Quite High
GABAergic 12 29.64 Quite Low
Central nervous system 5 10.92 Low Low
cINOD 14 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
African Trypanosomiasis 7 100.00 Very High Very High Very High
Colon Cancer 66 99.84 Very High Very High Very High
Targeted Disruption 80 98.08 Very High Very High Very High
Coronary Artery Disease 2 95.80 Very High Very High Very High
Colorectal Cancer 2 95.52 Very High Very High Very High
Cancer 128 94.92 High High
Mevalonate Kinase Deficiency 116 93.08 High High
INFLAMMATION 42 89.28 High High
Dementia 2 86.80 High High
Infection 9 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that HMG-CoA reductase is upregulated in colon cancer came from two large clinical trials designed to study the changes in coronary events in coronary heart disease.
Positive_regulation (upregulated) of HMG-CoA reductase in heart associated with coronary artery disease and colon cancer
1) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.96 Pain Relevance 0.04
The mechanism of the osteogenic effect of Rhizoma Drynariae can be partially explained by the activation of BMP-2 gene expression through the HMG-CoA reductase inhibition effect of naringin.
Positive_regulation (activation) of HMG-CoA
2) Confidence 0.14 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.08 Pain Relevance 0
The current review will focus on the upregulation of COX-2 and HMG-CoA reductase enzymes and the signaling cascades that are altered as a result of this up-regulation.
Positive_regulation (upregulation) of HMG-CoA reductase
3) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 1.36 Pain Relevance 0.04
Previous work showed that this is due to an increased activity of HMG-CoA reductase, which leads to elevated levels of mevalonate and a virtually normal flux through the isoprenoid biosynthesis pathway (Gibson et al 1990; Hoffmann et al 1997; Houten et al 2003b).
Positive_regulation (increased) of HMG-CoA reductase
4) Confidence 0.09 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.49 Pain Relevance 0.19
This is due to increased activity of HMG-CoA reductase, which leads to elevated levels of mevalonate and a virtually normal flux through the isoprenoid biosynthesis pathway (Gibson et al 1990; Hoffmann et al 1997; Houten et al 2003b).
Positive_regulation (increased) of HMG-CoA reductase
5) Confidence 0.06 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.41 Pain Relevance 0
In 1903, Ludwig Benda working for Cassella Farbwerke near Frankfurt synthesised a derivative of Nagana Red, called Trypan Red (Fig. 1), with an extra sulphonic acid function and enhanced water solubility [10].
Positive_regulation (derivative) of Red associated with african trypanosomiasis
6) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2848007 Disease Relevance 0.81 Pain Relevance 0
8 M and lower ones, induced glutamate efflux (red, Fig. 3B).
Positive_regulation (induced) of red associated with glutamate
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.08 Pain Relevance 0.24
mutants losing both redBA and gam loci induced by chrysotiles at a dose of 1 ?
Positive_regulation (induced) of redBA
8) Confidence 0.02 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC1797839 Disease Relevance 0.40 Pain Relevance 0
Simultaneous inactivations of both the redBA and gam genes, an indication of deletions in the gene loci region, provide an available method to quantify deletion mutations induced by various physical and chemical mutagens, such as X rays and alkylating agents (Horiguchi et al. 2001; Shibata et al. 2005).
Positive_regulation (inactivations) of redBA
9) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.26 Pain Relevance 0
Our results demonstrated that chrysotiles induced a dose dependent increase in mutant yield at the gam and redBA loci in MEF cells and that the incidence and types of mutants generated were comparable to those induced by equitoxic doses of H2O2.
Positive_regulation (increase) of redBA
10) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.21 Pain Relevance 0

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