INT2037

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 15.05
Pain Relevance 6.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
tear 1
plasma 1
BUCs 1
saliva 1
Urine 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 37 99.90 Very High Very High Very High
tetrodotoxin 115 99.66 Very High Very High Very High
peptic ulcer disease 10 99.66 Very High Very High Very High
sodium channel 410 99.08 Very High Very High Very High
cytokine 70 98.72 Very High Very High Very High
interstitial cystitis 9 97.60 Very High Very High Very High
substance P 9 96.98 Very High Very High Very High
adenocard 11 93.20 High High
Nav1.7 65 87.12 High High
chemokine 23 84.72 Quite High
Disease Link Frequency Relevance Heat
Colorectal Cancer 7 99.84 Very High Very High Very High
Exanthema 16 99.70 Very High Very High Very High
Cancer 360 99.68 Very High Very High Very High
Disease 62 99.66 Very High Very High Very High
Non-small-cell Lung Cancer 12 99.52 Very High Very High Very High
Ulcers 8 99.50 Very High Very High Very High
Peptic Ulcer 8 98.84 Very High Very High Very High
Apoptosis 318 98.80 Very High Very High Very High
Syndrome 5 98.80 Very High Very High Very High
Breast Cancer 58 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF levels significantly decreased by 33% after indomethacin (p < 0.03), and this decrement was linearly related to serum indomethacin concentrations (r = 0.58; p < 0.048).
Negative_regulation (decreased) of EGF
1) Confidence 0.59 Published 1994 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8273807 Disease Relevance 0.06 Pain Relevance 0.18
Since EGF is important in gastric mucosal protection, we questioned whether the potential ulcerogenic properties of indomethacin were related in part to decreasing salivary EGF.
Spec (whether) Negative_regulation (decreasing) of EGF
2) Confidence 0.51 Published 1994 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8273807 Disease Relevance 0.08 Pain Relevance 0.24
In vitro, preclinical in vivo and clinical studies have shown efficacy of epidermal growth factor signalling inhibition in colorectal cancer.
Negative_regulation (inhibition) of epidermal growth factor associated with colorectal cancer
3) Confidence 0.48 Published 2005 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15709983 Disease Relevance 1.86 Pain Relevance 0.41
This study was undertaken to determine whether patients with endoscopically proven active peptic ulcer disease have a salivary deficiency of human epidermal growth factor (hEGF), compared to patients with a normal esophagogastroduodenoscopy (EGD).
Spec (whether) Negative_regulation (deficiency) of epidermal growth factor associated with peptic ulcer disease and disease
4) Confidence 0.47 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2389722 Disease Relevance 0.47 Pain Relevance 0.17
This study was undertaken to determine whether patients with endoscopically proven active peptic ulcer disease have a salivary deficiency of human epidermal growth factor (hEGF), compared to patients with a normal esophagogastroduodenoscopy (EGD).
Spec (whether) Negative_regulation (deficiency) of hEGF associated with peptic ulcer disease and disease
5) Confidence 0.47 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2389722 Disease Relevance 0.47 Pain Relevance 0.17
Thus we developed the hypothesis that NSAIDs may limit the activity of EGF by altering intracellular Ca++ ([Ca++]i) mobilization.
Negative_regulation (limit) of EGF associated with cinod
6) Confidence 0.43 Published 2000 Journal J. Gastrointest. Surg. Section Abstract Doc Link 10675238 Disease Relevance 0.41 Pain Relevance 0.52
Based on this data, we concluded that indomethacin's ulcerogenic properties may be related to its prostaglandin inhibitory properties as well as its ability to decrease salivary EGF output.
Negative_regulation (decrease) of EGF
7) Confidence 0.43 Published 1994 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8273807 Disease Relevance 0 Pain Relevance 0
Cells were then incubated in one of the following: (1) EGF; (2) TTX; (3) EGF+TTX; (4) AG1478; an inhibitor of EGF receptor tyrosine kinase [53] or (5) EGF+AG1478.
Negative_regulation (inhibitor) of EGF associated with tetrodotoxin
8) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.21 Pain Relevance 0.36
Application of 100 nM AG1478, an inhibitor of EGF receptor, alone had the opposite effect, reducing cell invasion by 19 ± 5.4 % (p = 0.02, n = 4; Fig. 2E).
Negative_regulation (inhibitor) of EGF
9) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.21
Cells were then incubated in one of the following: (1) EGF; (2) TTX; (3) EGF+TTX; (4) AG1478; an inhibitor of EGF receptor tyrosine kinase [53] or (5) EGF+AG1478.
Negative_regulation (inhibitor) of EGF associated with tetrodotoxin
10) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.21 Pain Relevance 0.36
AG1478 also suppressed the effect of exogenous EGF in upregulating total VGSC protein expression; there was no difference in the levels of VGSC protein expression for EGF+AG1478 and AG1478 (p > 0.05; n = 6; Fig. 3B &3C).
Negative_regulation (suppressed) of EGF associated with sodium channel
11) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.84
The effect of EGF (exogenous and endogenous) in increasing VGSC protein expression was also apparent in plasma membrane (PM).
Negative_regulation (effect) of EGF in plasma associated with sodium channel
12) Confidence 0.40 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.71
Recent evidence suggests the probable identity of hEGF and beta-urogastrone, a potent inhibitor of gastric acid secretion.
Negative_regulation (inhibitor) of hEGF
13) Confidence 0.37 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 318106 Disease Relevance 0.48 Pain Relevance 0.17
Substance P-induced stimulation of Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor.
Negative_regulation (inhibitor) of epidermal growth factor associated with substance p
14) Confidence 0.34 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.49 Pain Relevance 0.50
Previous studies by others have shown that EGF was decreased in tear fluid from Sjögren’s syndrome patients [18], and also in those patients with DED but without MGD [31].
Negative_regulation (decreased) of EGF in tear associated with syndrome, disease and eye disease
15) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.26 Pain Relevance 0.36
EGF-R and HER-2 combined targeted tyrosine-kinase inhibitors
Negative_regulation (inhibitors) of EGF-R
16) Confidence 0.29 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.20 Pain Relevance 0.08
EGF-R-targeted tyrosine-kinase inhibitors
Negative_regulation (inhibitors) of EGF-R
17) Confidence 0.29 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.23 Pain Relevance 0.03
Inhibition of EGF receptor tyrosine kinase activity by AG1478 (5 ?
Negative_regulation (Inhibition) of EGF
18) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.08 Pain Relevance 0
Additionally, Mcl-1 downregulation sensitized cells towards chemotherapy combined with MEK1, Raf I kinase, mTOR, VEFG/PDGF receptor tyrosine kinase, or EGF receptor tyrosine kinase inhibition (Fig. 5A, and data not shown).
Negative_regulation (inhibition) of EGF
19) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.57 Pain Relevance 0
Furthermore, APF regulates expression of other cytokines, including upregulating heparin-binding epidermal growth factor-like growth factor and downregulating epidermal growth factor by BUCs.
Negative_regulation (downregulating) of epidermal growth factor in BUCs associated with cytokine
20) Confidence 0.22 Published 2006 Journal Curr Urol Rep Section Abstract Doc Link 17052438 Disease Relevance 0.51 Pain Relevance 0.47

General Comments

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