INT20371

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2011
Negated 9
Speculated 3
Reported most in Body
Documents 125
Total Number 128
Disease Relevance 67.59
Pain Relevance 8.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 59
B cells 6
lungs 4
lymphocytes 3
thymocytes 3
Cd8a (Mus musculus)
Cd8a - V599E (1)
Pain Link Frequency Relevance Heat
cytokine 894 99.98 Very High Very High Very High
Multiple sclerosis 330 99.84 Very High Very High Very High
qutenza 10 99.82 Very High Very High Very High
Inflammation 704 99.08 Very High Very High Very High
Morphine 7 98.80 Very High Very High Very High
Neuritis 8 98.48 Very High Very High Very High
Arthritis 28 97.56 Very High Very High Very High
tolerance 143 95.88 Very High Very High Very High
Sicca syndrome 45 95.68 Very High Very High Very High
Nerve growth factor 1 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1670 100.00 Very High Very High Very High
Influenza Virus Infection 762 100.00 Very High Very High Very High
Death 257 100.00 Very High Very High Very High
Lymphatic System Cancer 199 99.88 Very High Very High Very High
Respiratory Syncytial Virus 944 99.84 Very High Very High Very High
Demyelinating Disease 363 99.84 Very High Very High Very High
Adhesions 64 99.80 Very High Very High Very High
Convulsion 13 99.74 Very High Very High Very High
Leukemia 126 99.68 Very High Very High Very High
Infection 1901 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Purified CD8+ T cells and CD8- cells were suspended in PBS at 1 × 107 cells/ml.
Gene_expression (Purified) of CD8 in T cells
1) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0 Pain Relevance 0
Table 1 shows the frequency of CD8+ and CD4+ T cells and the corresponding influenza-specific CTL activity in the CD8- and CD8+ fractions after positive isolation of CD8+ T cells in a typical experiment.
Gene_expression (fractions) of CD8 in T cells associated with influenza virus infection
2) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.81 Pain Relevance 0
Protective effects of NP-specific CD8+
Gene_expression (specific) of CD8
3) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.35 Pain Relevance 0
Table 1 shows the frequency of CD8+ and CD4+ T cells and the corresponding influenza-specific CTL activity in the CD8- and CD8+ fractions after positive isolation of CD8+ T cells in a typical experiment.
Gene_expression (fractions) of CD8 in T cells associated with influenza virus infection
4) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.82 Pain Relevance 0
Protective effects of NP-specific CD8+
Gene_expression (effects) of CD8
5) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.36 Pain Relevance 0
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Gene_expression (cocultured) of CD8 in T cells
6) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
Recent studies reported that one population of CD8+Tregs was associated with Foxp3 expression [41-43], we further examined the expression of Foxp3 by CD8+CD94+T cells.
Spec (examined) Gene_expression (expression) of CD8 in T cells
7) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
To detect IL-10 and TGF-beta1 production, freshly isolated splenic CD8+CD94+T or CD8+CD94-T cells from various groups of mice were cultured in the 96-well plates containing PECs(1 × 105/well) and OVA(100 ?
Gene_expression (cultured) of CD8 in T cells
8) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
We first examined the expression of CD94 and NKG2A on splenic CD8+T cells.
Spec (examined) Gene_expression (expression) of CD8 in T cells
9) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0.07
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Gene_expression (heterodimer) of CD8 in T cells associated with immunization
10) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.15 Pain Relevance 0.08
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Gene_expression (expression) of CD8 in T cells associated with immunization
11) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.15 Pain Relevance 0.08
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Gene_expression (Expression) of CD8 in T cells
12) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Gene_expression (cocultured) of CD8 in T cells
13) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
As shown in Figure 3, the expression of intracellular granzyme B, perforin and Foxp3 in fresh CD8+CD94+T cells was minimal(~0.04%, ~0.01% and ~0.01%) in ACAID mice, immunized mice, PBS-AC-injected mice and naïve mice.
Gene_expression (expression) of CD8 in T cells
14) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
To detect IL-10 and TGF-beta1 production, freshly isolated splenic CD8+CD94+T or CD8+CD94-T cells from various groups of mice were cultured in the 96-well plates containing PECs(1 × 105/well) and OVA(100 ?
Gene_expression (cultured) of CD8 in T cells
15) Confidence 0.58 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
CD4+ and CD8a+ T lymphocytes were stained with CD3-PE, CD4-PerCP and CD8a-FITC.
Gene_expression (stained) of CD8a in T lymphocytes
16) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.31 Pain Relevance 0
CD4+ and CD8a+ T lymphocytes were stained with CD3-PE, CD4-PerCP and CD8a-FITC.
Gene_expression (stained) of CD8a in T lymphocytes
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.35 Pain Relevance 0
Using DNA microarray analysis, Keino et al[17] compared patterns of gene expression in regulatory OT-1 CD8+T cells generated in vitro with those from nonregulatory OT-1 CD8+T cells.
Gene_expression (expression) of CD8 in T cells
18) Confidence 0.50 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
Furthermore, a very high proportion of these circulating T cells showed an immature phenotype (i.e. 13.2% of PNA+CD3+ cells in stressed mice versus 1.3% in control mice) but they are not CD4+CD8+ thymocytes.
Neg (not) Gene_expression (thymocytes) of CD8 in thymocytes
19) Confidence 0.50 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.35 Pain Relevance 0
These results indicated that 667-involving cellular ICs enhance CD8+ T-cell responses in vivo.

667 enhances uptake of infected cells and induces more efficient activation of DCs

Gene_expression (responses) of CD8 in T-cell
20) Confidence 0.46 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0 Pain Relevance 0

General Comments

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