INT203710

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0

oxidoreductase activity (AKR7A2) Golgi apparatus (AKR7A2) carbohydrate metabolic process (AKR7A2) cytoplasm (AKR7A2)

Anatomy Link Frequency Muscle 1 AKR7A2 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 5 5.00 headache 3 5.00 corticosteroid 1 5.00 peripheral neuropathy 1 5.00 Paresthesia 1 5.00 dysesthesia 1 5.00

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 1 94.72 Ocular Toxicity (including Many Sub-types) 3 91.04 Leber Hereditary Optic Atrophy 27 77.52 Frailty 1 64.92 Blindness 2 45.28 Optic Disorders 4 10.56 Nicotine Addiction 6 5.00 Nausea 3 5.00 Headache Disorders 2 5.00 Asthenia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Muscle biopsy showed nonspecific changes, with an observable parcellar subsarcolemmal increase of succinic dehydrogenase staining, indicating some mitochondrial proliferation.

Positive_regulation (increase) of succinic dehydrogenase in Muscle

1) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797843 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.