INT20372

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 18.33
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
T cell 5
Th2 cells 3
spleen 2
granulocyte 2
lymph node 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 456 100.00 Very High Very High Very High
Inflammation 480 99.64 Very High Very High Very High
Inflammatory response 26 89.60 High High
dexamethasone 12 87.28 High High
Arthritis 72 85.88 High High
Pain 11 84.24 Quite High
Crohn's disease 3 60.28 Quite High
chemokine 42 60.16 Quite High
Infliximab 52 50.00 Quite Low
cINOD 10 45.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 56 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Asthma 468 99.68 Very High Very High Very High
INFLAMMATION 503 99.64 Very High Very High Very High
Sprains And Strains 247 99.52 Very High Very High Very High
Pneumonia 202 99.38 Very High Very High Very High
Stress 106 99.02 Very High Very High Very High
Hypersensitivity 218 98.48 Very High Very High Very High
Disease 263 96.08 Very High Very High Very High
Adhesions 26 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Localization (secretion) of IL-5 associated with asthma and cytokine
1) Confidence 0.41 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.10
Interleukin-5 measurement
Localization (measurement) of Interleukin-5
2) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0 Pain Relevance 0.11
Allergen exposure has been shown to be associated with release of IL-5 and IL-13 from inflammatory cells in allergic airway exposure and associated with oxidative stress in BALB/c mice [37].
Localization (release) of IL-5 associated with stress, inflammation and hypersensitivity
3) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994734 Disease Relevance 1.58 Pain Relevance 0.38
In vitro studies on primary cultures of purified human CD4+ T cells showed evidence that oxidative stress could be induced which in turn modulated T cell polarization toward Th2 cytokine producing cells, including IL-4, IL-5, and IL-13 [38].
Localization (polarization) of IL-5 in T cell associated with stress and cytokine
4) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994734 Disease Relevance 1.43 Pain Relevance 0.42
IL-5 secretion from Th2 cells.
Localization (secretion) of IL-5 in Th2 cells
5) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 1.07 Pain Relevance 0.15
The cytokine profile of CD8+ clones is representative of that secreted by activated normal CD8+ splenocytes, which includes IFN-gamma, low levels of IL-2 and IL-3 but no IL-4 or IL-5.
Localization (secreted) of IL-5 associated with cytokine
6) Confidence 0.35 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.21
In this model, the inflammation is characterized by increased IL-4 and IL-5 secretion and the inflammation can be ameliorated by the administration of anti-IL-4 antibodies (15).
Localization (secretion) of IL-5 associated with inflammation
7) Confidence 0.33 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.11 Pain Relevance 0.13
Further, airway eosinophils were shown not to release eosinophil-derived neurotoxin (EDN) when treated with IL-5 compared with their blood counterparts.
Neg (not) Localization (treated) of IL-5 in eosinophils
8) Confidence 0.32 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.41 Pain Relevance 0.03
It is interesting that Liu and colleagues later showed a marked reduction in the expression of messenger ribonucleic acid of the surface IL-5 receptor (mIL-5R?)
Localization (receptor) of IL-5
9) Confidence 0.32 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.39 Pain Relevance 0
Enzyme immunoassays were performed as described before[23,27] using monoclonal Ab (anti-IL-2, anti-IL-4, anti-IL-5, anti-IL-12, anti-IFN-?
Localization (anti) of IL-5
10) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0 Pain Relevance 0.05
Allergic diseases are characterized by elevated serum IgE, an inflammatory reaction with increased number of eosinophils, mast cells and an adaptative immune responses orchestrated by Th2-like CD4+ memory T cells secreting an array of cytokines such as IL-4, IL-5 and IL-13.
Localization (secreting) of IL-5 in memory T cells associated with inflammation, hypersensitivity, disease and cytokine
11) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.67 Pain Relevance 0.10
Blood samples were analysed for leukocyte subset cell counts, in vitro T-cell mitogen-stimulated cytokine production (IL-2, IL-4, IL-5, IL-6, IL-10, TNF-alpha and IFN-gamma) and in vitro monocyte cytokine release (IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha) in response to increasing concentrations of LPS.
Localization (release) of IL-5 in T-cell associated with cytokine
12) Confidence 0.27 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17553664 Disease Relevance 0.34 Pain Relevance 0.36
PspA199–249-specific HTLs from S. pneumonia strain EF3030-challenged mice secreted significant amounts of IL-4 (spleen>>CLN) and IL-5 (spleen?
Localization (secreted) of IL-5 in spleen associated with pneumonia and sprains and strains
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.64 Pain Relevance 0.20
, IL-10, IL-2, IL-4 and IL-5 secretion by CLN and splenic CD4+ T cells from S. pneumonia strain EF3030-challenged mice was higher than the naïve group.
Localization (secretion) of IL-5 in T cells associated with pneumonia and sprains and strains
14) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.55 Pain Relevance 0.04
Similar CLN Th2 cells secreted IL-4 in response to peptides 19 and 20 whereas heightened IL-5 secretion was noted in response to peptides 19 to 22 as well as 29 and 35, than compared to naive mice.
Localization (secretion) of IL-5 in Th2 cells
15) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.65 Pain Relevance 0.03
While cells from naïve mice did not significantly respond to PspA peptides, CD4+ T lymphocytes from S. pneumonia strain EF3030-challenged mice also significantly secreted IL-4 and IL-5 after PspA peptide ex vivo stimulation (Figures 6 and 7).
Localization (secreted) of IL-5 in T lymphocytes associated with pneumonia and sprains and strains
16) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.73 Pain Relevance 0.06
PspA199–249-specific HTLs from S. pneumonia strain EF3030-challenged mice secreted significant amounts of IL-4 (spleen>>CLN) and IL-5 (spleen?
Localization (amounts) of IL-5 in spleen associated with pneumonia and sprains and strains
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.63 Pain Relevance 0.19
, IL-2, IL-4, and IL-5 were measured.
Localization (measured) of IL-5
18) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.55 Pain Relevance 0.22
IL-5 is essential for maturation of eosinophils in the bone marrow and their release into the blood [27,28].
Localization (release) of IL-5 in bone marrow
19) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.86 Pain Relevance 0.29
It is known that interleukin-1 (IL-1), interleukin-5 (IL-5), NFkB, granulocyte colony stimulating factor, tumor necrosis factor and many other cytokines are released from the HRS cells (1,28).
Localization (released) of interleukin-5 in granulocyte associated with necrosis, cancer and cytokine
20) Confidence 0.20 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 1.01 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox