INT203727

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.54
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
bone marrow 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 81.96 Quite High
Inflammation 118 61.64 Quite High
cytokine 29 24.24 Low Low
Inflammatory stimuli 1 22.44 Low Low
agonist 15 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 252 99.98 Very High Very High Very High
Colorectal Cancer 1 99.80 Very High Very High Very High
Targeted Disruption 11 98.24 Very High Very High Very High
Pancreatic Cancer 1 96.96 Very High Very High Very High
Prostate Cancer 1 95.68 Very High Very High Very High
Colon Cancer 11 94.44 High High
Obesity 21 94.16 High High
Weight Gain 4 92.64 High High
Injury 12 86.68 High High
INFLAMMATION 136 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-deficient bone marrow cells, when transplanted into WT hosts, conferred the tumor-suppressing phenotype of PPAR?
Negative_regulation (suppressing) of Phosphorylation (phenotype) of PPAR in bone marrow associated with cancer
1) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.75 Pain Relevance 0.04
Another study reports that 8% of primary colorectal tumors harbor a loss of function mutation in one allele of the PPAR-?
Negative_regulation (loss) of Phosphorylation (allele) of PPAR associated with colorectal cancer
2) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.79 Pain Relevance 0
However, despite ablation of PPAR?
Negative_regulation (despite) of Phosphorylation (ablation) of PPAR
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0
insulin-signaling pathway that inhibits S112 phosphorylation of PPAR?
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of PPAR
4) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 1.00 Pain Relevance 0.03

General Comments

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