INT20373

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1990
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 8.22
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 18
lymph nodes 1
lymphocytes 1
B cells 1
dendritic cells 1
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 135 100.00 Very High Very High Very High
Central nervous system 56 99.98 Very High Very High Very High
chemokine 1 99.68 Very High Very High Very High
Enkephalin 3 99.60 Very High Very High Very High
Inflammation 105 98.50 Very High Very High Very High
Potency 3 89.64 High High
midbrain 1 88.28 High High
Hippocampus 4 87.88 High High
rheumatoid arthritis 61 81.48 Quite High
tolerance 29 69.44 Quite High
Disease Link Frequency Relevance Heat
Convulsion 14 99.74 Very High Very High Very High
Influenza Virus Infection 146 99.44 Very High Very High Very High
Immunization 106 98.92 Very High Very High Very High
Infection 227 98.84 Very High Very High Very High
Viral Infection 22 98.68 Very High Very High Very High
INFLAMMATION 111 98.50 Very High Very High Very High
Cytomegalovirus Infection 4 98.04 Very High Very High Very High
Shock 1 96.28 Very High Very High Very High
Herpes Simplex Virus 19 95.24 Very High Very High Very High
Metaplasia 22 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Purified CD8+CD94+T cells from two groups displayed hyporesponsiveness to stimulation with anti-CD3 mAb, whereas CD8+CD94-T cells proliferated strongly (Fig. 4B).
Localization (Purified) of CD8 in T cells
1) Confidence 0.64 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.06 Pain Relevance 0
Purified CD8+CD94+T cells from two groups displayed hyporesponsiveness to stimulation with anti-CD3 mAb, whereas CD8+CD94-T cells proliferated strongly (Fig. 4B).
Localization (Purified) of CD8 in T cells
2) Confidence 0.64 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
To detect IL-10 and TGF-beta1 production, freshly isolated splenic CD8+CD94+T or CD8+CD94-T cells from various groups of mice were cultured in the 96-well plates containing PECs(1 × 105/well) and OVA(100 ?
Localization (isolated) of CD8 in T cells
3) Confidence 0.64 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
To detect IL-10 and TGF-beta1 production, freshly isolated splenic CD8+CD94+T or CD8+CD94-T cells from various groups of mice were cultured in the 96-well plates containing PECs(1 × 105/well) and OVA(100 ?
Localization (isolated) of CD8 in T cells
4) Confidence 0.64 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Interestingly, CD8+CD94+T cells from ACAID mice secreted larger amounts of TGF-beta1 as compared with CD8+CD94-T cells from these mice.
Localization (secreted) of CD8 in T cells
5) Confidence 0.60 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.17 Pain Relevance 0
secretion by pulmonary CD8 T cells is independent of local viral infection.
Localization (secretion) of CD8 in T cells associated with viral infection
6) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 0.46 Pain Relevance 0
At 24h after a maximal seizure, CD4(+) and CD8(+) T cells and CD45R(+) B cells appeared in brain, reaching peak numbers at 48 h, but were no longer detected at 7days.
Localization (appeared) of CD8 in B cells associated with convulsion
7) Confidence 0.46 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 19822204 Disease Relevance 1.11 Pain Relevance 0.21
Inasmuch as many Th1/Th2 functions are cytokine mediated, the striking similarity of the Th1 and CD8+ cytokine secretion patterns helps to explain why these two cell types share certain functions such as DTH, and also suggests that further common functions may be discovered in the future.
Localization (secretion) of CD8 associated with cytokine
8) Confidence 0.43 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.21
The cytokine profile of CD8+ clones is representative of that secreted by activated normal CD8+ splenocytes, which includes IFN-gamma, low levels of IL-2 and IL-3 but no IL-4 or IL-5.
Localization (secreted) of CD8 associated with cytokine
9) Confidence 0.40 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.21
The efficiency of IDLV observed in our and in other models [27], in terms of quantity, persistence, and quality of CD8+ T cell response, could be reasonably considered an excellent beginning for future exploitation of this vector for developing vaccine strategies aimed at inducing CD8+ T cell responses.
Localization (response) of CD8 in T cell
10) Confidence 0.40 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873659 Disease Relevance 0.28 Pain Relevance 0.04
Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.
Localization (secrete) of CD8 in T cell associated with enkephalin and cytokine
11) Confidence 0.33 Published 1990 Journal J. Immunol. Section Title Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.29
We then assessed whether T cell proliferation plays a role in these observed alterations of CD4+ and CD8+ T cell percentages during the induction and expression of ACAID.
Localization (alterations) of CD8 in T cell
12) Confidence 0.32 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.43 Pain Relevance 0
Single cell suspensions of mouse lymph nodes and spleens were prepared as described previously [72] and CD4+ as well as CD8+ T cells were separated by negative enrichment using magnetic beads (Miltenyi Biotech, Bergisch Gladbach, Germany).
Neg (negative) Localization (separated) of CD8 in lymph nodes
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.09 Pain Relevance 0
Since both CD11c and CD80 are expressed widely on murine APC we asked whether the presence of CD11c on CD8+ T cells is due to expression by T cells rather than to membrane transfer from APC during T cell priming.
Spec (whether) Localization (presence) of CD8 in T cell
14) Confidence 0.28 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.47 Pain Relevance 0
Purified murine or human CD8+ and CD4+ T cells were stimulated three times per day for 2 days with either PBS or ?
Localization (murine) of CD8 in T cells
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.26 Pain Relevance 0.03
Upon viral challenge of vaccinated mice, effector CD4+ and CD8+ lymphocytes were rapidly recruited to the BAL.
Localization (lymphocytes) of CD8 in lymphocytes
16) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.88 Pain Relevance 0.06
CD28 ligation increases the proliferative response of both CD4+ and CD8+ T cell subsets via these molecular pathways.
Localization (response) of CD8 in T cell
17) Confidence 0.18 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.11
Cells were harvested, washed, stained for 30 min on ice with FITC-coupled anti-CD8 mAb, washed again, fixed for 15 min at 4°C with 1% formalin, permeabilized for 10 min at RT in PBS containing 0.5% saponin and 1% BSA, stained for 30 min on ice with PE-coupled rat anti-IFN-?
Localization (coupled) of CD8
18) Confidence 0.16 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.42 Pain Relevance 0.04
Flow cytometric analysis showed that CD45 positive NA-BMCs were positive for CD11b, CD90 and had low amounts of CD4+, CD8+, CD19+, and CD117+ cells.
Localization (amounts) of CD8
19) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.25 Pain Relevance 0.03
Under this hypothesis, the population released to the periphery as CD4 or CD8 naïve T cells would be smaller than normal, but already enriched for correcting alleles.
Localization (released) of CD8 in T cells
20) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox