INT20374

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Context Info
Confidence 0.76
First Reported 1981
Last Reported 2011
Negated 21
Speculated 8
Reported most in Body
Documents 515
Total Number 525
Disease Relevance 306.15
Pain Relevance 114.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 70
Th2 cells 16
lung 11
mast cells 10
lymphocyte 8
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11065 100.00 Very High Very High Very High
Inflammation 7776 100.00 Very High Very High Very High
chemokine 1400 100.00 Very High Very High Very High
Inflammatory response 662 100.00 Very High Very High Very High
Nerve growth factor 379 100.00 Very High Very High Very High
COX2 6 100.00 Very High Very High Very High
Inflammatory mediators 160 99.90 Very High Very High Very High
rheumatoid arthritis 1961 99.84 Very High Very High Very High
Central nervous system 552 99.84 Very High Very High Very High
tolerance 395 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8323 100.00 Very High Very High Very High
Infection 5269 100.00 Very High Very High Very High
Cancer 4043 100.00 Very High Very High Very High
Targeted Disruption 1323 100.00 Very High Very High Very High
Necrosis 530 100.00 Very High Very High Very High
Adhesions 376 100.00 Very High Very High Very High
Eosinophilia 267 99.90 Very High Very High Very High
Asthma 5789 99.88 Very High Very High Very High
Rheumatoid Arthritis 2023 99.84 Very High Very High Very High
Respiratory Syncytial Virus 467 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CNS delivery of the d120:LacZ:IL-4 vector, after EAE onset, induced the in situ production of IL-4 by CNS-resident cells facing the cerebrospinal fluid (CSF) spaces and reduced by 47% (P < 0.02) the disease-related deaths.
Gene_expression (production) of IL-4 in cerebrospinal fluid associated with multiple sclerosis, central nervous system and disease
1) Confidence 0.76 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 2.03 Pain Relevance 0.68
At the cell level, the hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 cytokines produced by T helper cells (type 1 and 2).
Gene_expression (expressions) of interleukin-4 in mast cells associated with cytokine
2) Confidence 0.75 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19557358 Disease Relevance 0.87 Pain Relevance 0.15
Prolonged N. brasiliensis infection, due to a deficiency in smooth muscle cell expression of IL-4R?
Gene_expression (expression) of IL-4 in smooth muscle cell associated with infection
3) Confidence 0.75 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.37 Pain Relevance 0.17
Urease site 8 overlaps with an established H. pylori CD4+ T-cell epitope, in response to which splenic lymphocytes produce cytokine IL-4 [18], a promoter of Th2 responses and driver of antibody production.
Gene_expression (produce) of IL-4 in lymphocytes associated with cytokine
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993952 Disease Relevance 0.31 Pain Relevance 0.05
None of the well-defined asthma/inflammatory genes (Il1b, Il4, Il10, Il13, Il6, Tnfa, Infg, Tgfb1) are differentially expressed, although they connect many of the genes that are.
Gene_expression (expressed) of Il4 associated with asthma and inflammation
5) Confidence 0.73 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.27 Pain Relevance 0.34
Immune functions were evaluated by the ability of splenocytes to reduce a tetrazolium salt to formazan (MTT test), to proliferate, and to produce cytokines, including interleukin (IL)-1, IL-2, IL-4, IL-6, IL-10 and interferon gamma (IFN gamma).
Gene_expression (produce) of IL-4 associated with cytokine
6) Confidence 0.67 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.14 Pain Relevance 0.70
We injected into the cisterna magna (i.c.) of Biozzi AB/H mice affected by a relapsing-remitting form of experimental autoimmune encephalomyelitis (EAE), the animal model of MS, a non-replicative herpes simplex virus (HSV) type-1-derived vector containing the interleukin (IL)-4 gene (d120:LacZ:IL-4).
Gene_expression (containing) of IL-4 associated with multiple sclerosis, cold sores and herpes simplex virus
7) Confidence 0.66 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 2.00 Pain Relevance 0.67
The mucus production was delayed in SM-MHCCreIL-4R??
Gene_expression (production) of IL-4
8) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.71 Pain Relevance 0.03
Analysis of IL-4R?
Gene_expression (Analysis) of IL-4
9) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0 Pain Relevance 0
As expected [15], IL-4R??
Gene_expression (expected) of IL-4
10) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.52 Pain Relevance 0.11
knockout mice and equivalent to levels expressed on transgenic Cre-negative IL-4R??
Gene_expression (expressed) of IL-4 associated with targeted disruption
11) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.45 Pain Relevance 0
/lox mice as by day 10 PI in goblet cell hyperplasia was comparable to levels observed in IL-4R??
Gene_expression (observed) of IL-4 in goblet cell associated with hyperplasia
12) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.69 Pain Relevance 0.03
knockout mice and equivalent to levels expressed on transgenic Cre-negative IL-4R??
Neg (negative) Gene_expression (negative) of IL-4 associated with targeted disruption
13) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.45 Pain Relevance 0
/lox and IL-4R??
Gene_expression (/) of IL-4
14) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.21 Pain Relevance 0.14
Together, these results provide convincing support for the specificity of smooth muscle cell disruption of IL-4R?
Gene_expression (disruption) of IL-4 in smooth muscle cell
15) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.51 Pain Relevance 0
Together, these data are suggestive of smooth muscle IL-4R?
Gene_expression (suggestive) of IL-4 in smooth muscle
16) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.48 Pain Relevance 0.18
As such, our demonstration of significant inhibition of M3 expression in IL-4R?
Gene_expression (expression) of IL-4
17) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.27 Pain Relevance 0.03
IL-13/IL-4R?
Gene_expression (/) of IL-4
18) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.81 Pain Relevance 0
Disruption of IL-4R?
Gene_expression (Disruption) of IL-4
19) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.52 Pain Relevance 0.07
Generation and genotyping of conditional IL-4R?
Gene_expression (Generation) of IL-4
20) Confidence 0.65 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.43 Pain Relevance 0.09

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