INT20375

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2011
Negated 3
Speculated 1
Reported most in Abstract
Documents 213
Total Number 219
Disease Relevance 148.51
Pain Relevance 54.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
T cells 28
Th1 cells 17
macrophages 8
lymphocytes 7
lung 5
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4052 100.00 Very High Very High Very High
Inflammation 3441 100.00 Very High Very High Very High
chemokine 855 100.00 Very High Very High Very High
Arthritis 1324 99.98 Very High Very High Very High
rheumatoid arthritis 1249 99.98 Very High Very High Very High
qutenza 28 99.82 Very High Very High Very High
Multiple sclerosis 907 99.66 Very High Very High Very High
withdrawal 31 99.52 Very High Very High Very High
Crohn's disease 230 99.48 Very High Very High Very High
cva 45 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3625 100.00 Very High Very High Very High
Disease 3109 100.00 Very High Very High Very High
Infection 2485 100.00 Very High Very High Very High
Autoimmune Disease 758 100.00 Very High Very High Very High
Rheumatoid Arthritis 1281 99.98 Very High Very High Very High
Lyme Disease 241 99.98 Very High Very High Very High
Colitis 413 99.88 Very High Very High Very High
Systemic Lupus Erythematosus 1017 99.84 Very High Very High Very High
Tick Infestations 24 99.80 Very High Very High Very High
Targeted Disruption 653 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A large panel of CD8+ mouse T cell clones expressed the cytokine synthesis pattern characteristic of Th1 clones.
Gene_expression (expressed) of Th1 in T cell associated with cytokine
1) Confidence 0.60 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.09
As expected, this agent increased LC3-II levels in all conditions (Fig. 6H and I), but after Bafilomycin A1 treatment, the levels of LC3-II were lower in cells expressing PSA siRNA (Fig. 6H and I) than in control cells (Fig. 6J and K).
Gene_expression (expressing) of H and I
2) Confidence 0.58 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.06 Pain Relevance 0
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Gene_expression (production) of Th1 associated with experimental autoimmune neuritis, neuritis and cytokine
3) Confidence 0.57 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.49
We present evidence that these effects could be mediated by the modulation of Th1/Th2 cytokine production.
Gene_expression (production) of Th1 associated with cytokine
4) Confidence 0.54 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.06 Pain Relevance 0.67
The level of IL-3 produced by CD8+ clones was approximately 10% of that produced by Th1 and Th2 clones.
Gene_expression (produced) of Th1
5) Confidence 0.52 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.18
CD8+ clones synthesized IFN-gamma and lymphotoxin at levels similar to Th1 clones, whereas IL-2 was synthesized by only 50% of the clones and at significantly lower levels compared to Th1 clones.
Gene_expression (synthesized) of Th1
6) Confidence 0.52 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.11
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Gene_expression (production) of Th1 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
7) Confidence 0.50 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.84 Pain Relevance 0.80
This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
Gene_expression (production) of Th1 associated with neuritis and cytokine
8) Confidence 0.50 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17218016 Disease Relevance 0.42 Pain Relevance 0.43
Moreover in C57BL/6 mice, naloxone treatment was able to accelerate skin-graft rejection, a Th1-mediated phenomenon, by increasing Th1 cytokine production.
Gene_expression (production) of Th1 in skin associated with narcan, graft vs host disease and cytokine
9) Confidence 0.48 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.10 Pain Relevance 0.84
This stress hormone has been reported to shift the immune response from Th1 to Th2 by the down-regulation of Th1 cytokine expression.
Gene_expression (expression) of Th1 associated with stress and cytokine
10) Confidence 0.47 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20408448 Disease Relevance 1.38 Pain Relevance 0.68
Therefore, in the context of chemical-induced asthma, it is not correct to state that a certain mouse strain is more Th2-biased than Th1-biased.
Gene_expression (biased) of Th1 associated with asthma and sprains and strains
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 1.41 Pain Relevance 0.03
We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones.
Gene_expression (overexpressed) of Th1 in regulatory T cells
12) Confidence 0.44 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.11
We have cloned CD4+ T cells against a male transplantation Ag that, unlike Th1 or Th2 clones, suppresses the rejection of male skin grafts and are therefore considered examples of regulatory T cells.
Gene_expression (suppresses) of Th1 in skin
13) Confidence 0.44 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.10 Pain Relevance 0.06
The results indicate that T-H suppresses cell proliferation, Th1 cytokine production, and MAPK activation in splenocytes.
Gene_expression (production) of Th1 associated with cva and cytokine
14) Confidence 0.44 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16807299 Disease Relevance 1.12 Pain Relevance 1.25
We found that cardiac Th cytokine responses after burn were specific for Th-17, as cardiac levels of Th-1 (IFN-?)
Gene_expression (levels) of Th-1 associated with burns and cytokine
15) Confidence 0.44 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.97 Pain Relevance 0.33
In the present paper, the expression of PPNK mRNA in purified CD4+ Th1 and Th2 lymphocyte subpopulations is investigated and correlated with the presence of the opioid neuropeptides leu- and met-enkephalin.
Gene_expression (expression) of Th1 in lymphocyte associated with neuropeptide, enkephalin and opioid
16) Confidence 0.41 Published 1999 Journal Immunol. Cell Biol. Section Abstract Doc Link 10540203 Disease Relevance 0 Pain Relevance 0.36
Production of the Th1 cytokine, IFN-?
Gene_expression (Production) of Th1 associated with cytokine
17) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.52 Pain Relevance 0.16
Following withdrawal, it was found that the Th1-polarizing cytokine IL-12 was significantly decreased, providing further support for the observation that withdrawal results in Th2 differentiation by possibly impacting the generation of an appropriate innate immune response which directs subsequent adaptive Th1/Th2 responses.
Gene_expression (decreased) of Th1 associated with withdrawal and cytokine
18) Confidence 0.40 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.33
Importantly, CXCR3-expressing T cells have been shown to predominantly produce Th1 cytokines and selectively mobilize Th1 and inflammatory lymphocytes [70].
Gene_expression (produce) of Th1 in T cells associated with inflammation and cytokine
19) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.83 Pain Relevance 0.41
To investigate local and peripheral changes in Th1 and inflammatory cytokine expression during CYP-induced cystitis, the levels of IFN-?
Gene_expression (expression) of Th1 associated with inflammation, cystitis and cytokine
20) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.43 Pain Relevance 0.17

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